Sugi Predict

Sugi Predict / Compounds / SCHEMBL5886488

SCHEMBL5886488

SCHEMBL5886488

COC(=O)c1nnc(Cl)cc1OC

nearest known ligand 0.44

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 6/20 0.44
▸ LMNA P02545 1/20 0.44
▸ L3MBTL1 Q9Y468 2/20 0.43
▸ RAB9A P51151 1/20 0.43
▸ GAA P10253 1/20 0.42
▸ NPSR1 Q6W5P4 1/20 0.42
▸ NOTUM Q6P988 1/20 0.40
▸ KDM4E B2RXH2 3/20 0.40
▸ GLA P06280 1/20 0.38
▸ KMT2A Q03164 1/20 0.38
▸ SYK P43405 1/20 0.38
▸ SMN1; SMN2 Q16637 1/20 0.38
▸ USP2 O75604 1/20 0.37
▸ POLB P06746 1/20 0.37
▸ HSD17B10 Q99714 1/20 0.37
▸ HTT P42858 1/20 0.37
▸ MAPT P10636 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31590096 1.00 ALDH1A1 (0.44) ALDH1A1LMNAL3MBTL1RAB9AGAA
SCHEMBL30632327 0.87 ALDH1A1 (0.42) ALDH1A1LMNAL3MBTL1RAB9ASYK
SCHEMBL24542675 0.87 ALDH1A1 (0.42) ALDH1A1LMNAL3MBTL1RAB9ASYK
SCHEMBL24587304 0.84 ALDH1A1 (0.42) ALDH1A1LMNAL3MBTL1RAB9AKDM4E
SCHEMBL30989604 0.84 ALDH1A1 (0.42) ALDH1A1LMNAL3MBTL1RAB9AKDM4E
SCHEMBL23291609 0.82 LMNA (0.54) ALDH1A1LMNAL3MBTL1GAAKDM4E
SCHEMBL1343778 0.81 NPSR1 (0.45) ALDH1A1LMNAL3MBTL1GAANPSR1
SCHEMBL29922648 0.81 NPSR1 (0.45) ALDH1A1LMNAL3MBTL1GAANPSR1
SCHEMBL20911423 0.80 NPSR1 (0.43) ALDH1A1LMNAL3MBTL1GAANPSR1
SCHEMBL21679164 0.80 NPSR1 (0.43) ALDH1A1LMNAL3MBTL1GAANPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260027096-A1 PHD INHIBITORS UNIV OXFORD INNOVATION LTD (GB) 2026-01-29 — — US disclosed
US-20260027095-A1 Compounds as Inhibitors of Macrophage Migration Inhibitory Factor and the Use Thereof NANJING IMMUNOPHAGE BIOTECH CO LTD (CN) 2026-01-29 — — US disclosed
EP-4655288-A1 PHD INHIBITORS Oxford University Innovation Limited (GB) 2025-12-03 — — EP disclosed
EP-4655294-A1 PYRAZOLE DERIVSTIVES AS PHD INHIBITORS Oxford University Innovation Limited (GB) 2025-12-03 — — EP disclosed
US-20250346602-A1 LACTAM SUBSTITUTED IMIDAZOPYRIDAZINE IL-17A MODULATORS AND USES THEREOF DICE ALPHA INC (US) 2025-11-13 — — US disclosed
EP-4642779-A1 COMPOUNDS AS INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR AND THE USE THEREOF Nanjing Immunophage Biotech Co., Ltd (CN) 2025-11-05 — — EP disclosed
CN-120040475-A Compounds as WRN inhibitors and uses thereof 南京圣和药业股份有限公司 2025-05-27 — — CN disclosed
US-20250136556-A1 NOVEL MODULATORS OF THE ARYL HYDROCARBON RECEPTOR AND METHODS OF USE THEREOF ALLIANTHERA BOSTON INC. 2025-05-01 — — US disclosed
EP-4525987-A1 LACTAM SUBSTITUTED IMIDAZOPYRIDAZINE IL-17A MODULATORS AND USES THEREOF Dice Alpha, Inc. (US) 2025-03-26 — — EP disclosed
CN-115279765-B 1H-pyrazolo [4,3-d ] pyrimidine compounds as Toll-like receptor 7 (TLR 7) agonists 百时美施贵宝公司 2024-11-12 — — CN disclosed
WO-2022159955-A1 SMALL MOLECULE REGULATORS OF ALVEOLAR TYPE 2 CELL PROLIFERATION FOR THE TREATMENT OF PULMONARY DISEASES THE SCRIPPS RESEARCH INSTITUTE (US) 2022-07-28 — — WO disclosed
WO-2021154669-A1 1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS BRISTOL-MYERS SQUIBB COMPANY (US) 2021-08-05 — — WO disclosed
EP-3740476-A1 C5A RECEPTOR MODULATORS Idorsia Pharmaceuticals Ltd (CH) 2020-11-25 — — EP disclosed
US-20200347029-A1 C5A RECEPTOR MODULATORS IDORSIA PHARMACEUTICALS LTD. (CH) 2020-11-05 — — US disclosed
CN-111615513-A C5a receptor modulators 爱杜西亚药品有限公司 2020-09-01 — — CN disclosed
WO-2019141803-A1 C5A RECEPTOR MODULATORS IDORSIA PHARMACEUTICALS LTD (CH) 2019-07-25 — — WO disclosed
US-7122546-B2 Imidazol-1-ylmethyl pyridazine derivatives NEUROGEN CORPORATION (US) 2006-10-17 — — US disclosed
EP-1549636-A1 IMIDAZOL-1-YLMETHYL PYRIDAZINE DERIVATIVES Neurogen Corporation (US) 2005-07-06 — — EP disclosed
US-20040077653-A1 Imidazol-1-ylmethyl pyridazine derivatives NEUROGEN CORPORATION 2004-04-22 — — US disclosed
WO-2004031174-A1 IMIDAZOL-1-YLMETHYL PYRIDAZINE DERIVATIVES NEUROGEN CORPORATION (US) 2004-04-15 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200347029-A1 C5A RECEPTOR MODULATORS C5AR1, C3AR1, C5AR2 ALDH1A1 2987/4885LMNA 3728/4885L3MBTL1 4376/4885
US-20250136556-A1 NOVEL MODULATORS OF THE ARYL HYDROCARBON RECEPTOR AND METHODS OF USE THEREOF AHR, ARNT, NR1H2 ALDH1A1 469/4885LMNA 4610/4885L3MBTL1 4012/4885
US-20260027096-A1 PHD INHIBITORS HIF1AN, HIF1A, EGLN1 ALDH1A1 113/4885LMNA 1934/4885L3MBTL1 215/4885
US-20250346602-A1 LACTAM SUBSTITUTED IMIDAZOPYRIDAZINE IL-17A MODULATORS AND USES THEREOF IL17A, IL15, IL18 ALDH1A1 392/4885LMNA 4192/4885L3MBTL1 4848/4885
US-20260027095-A1 Compounds as Inhibitors of Macrophage Migration Inhibitory Factor and the Use Thereof MIF, MSR1, CCR2 ALDH1A1 1403/4885LMNA 2863/4885L3MBTL1 1726/4885
US-20040077653-A1 Imidazol-1-ylmethyl pyridazine derivatives GABRA5, GABRA1, GABRA2 ALDH1A1 378/4885LMNA 2743/4885L3MBTL1 2983/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.