Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 2/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.41 |
| ▸ | CPA1 | P15085 | 1/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20047603 | 0.87 | FAAH (0.45) | MMEACECPA1ACE2MEN1 | |
| SCHEMBL25028556 | 0.85 | ACACB (0.39) | MMEACECPA1ACE2MEN1 | |
| SCHEMBL20047507 | 0.84 | RIPK1 (0.47) | MMEACECPA1ACE2FAAH | |
| SCHEMBL12308640 | 0.80 | ACE (0.39) | MMEACECPA1ACE2MEN1 | |
| SCHEMBL15895091 | 0.78 | MMP1 (0.42) | TDP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL23175980 | 0.77 | ALDH1A1 (0.40) | TDP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL23502572 | 0.77 | FAAH (0.42) | MMEACECPA1ACE2MEN1 | |
| SCHEMBL24176580 | 0.76 | TDP1 (0.39) | TDP1MEN1KMT2AALDH1A1RIPK1 | |
| SCHEMBL22251624 | 0.74 | MME (0.39) | MMEACECPA1ACE2MEN1 | |
| SCHEMBL2863541 | 0.74 | MME (0.39) | MMEACECPA1ACE2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7098207-B2 | Imidazotriazinones and the use thereof | BAYER PHARMACEUTICALS CORPORATION (US) | 2006-08-29 | — | — | US | disclosed |
| US-20050267112-A1 | Novel imidazotriazinones and the use thereof | BAYER AKTIENGESELLSCHAFT (US) | 2005-12-01 | — | — | US | disclosed |
| US-6878708-B2 | Imidazotriazinones and the use thereof | BAYER AKTIENGESELLSCHAFT (DE) | 2005-04-12 | — | — | US | disclosed |
| US-6858605-B2 | Substituted 2,3-benzodiazepine derivatives | IVAX DRUG RESEARCH INSTITUTE, LTD. (HU) | 2005-02-22 | — | — | US | disclosed |
| EP-1280805-B1 | NOVEL IMIDAZOTRIAZINONES AND THE USE THEREOF | BAYER HEALTHCARE AG (DE) | 2005-02-09 | — | — | EP | disclosed |
| US-20040152693-A1 | Novel substituted 2,3-benzodiazepine derivatives | IVAX DRUG RESEARCH INSTITUTE, LTD. | 2004-08-05 | — | — | US | disclosed |
| US-20040097498-A1 | Novel imidazotriazinones and the use thereof | BAYER AKTIENGESELLSCHAFT (DE) | 2004-05-20 | — | — | US | disclosed |
| EP-1280805-A1 | NOVEL IMIDAZOTRIAZINONES AND THE USE THEREOF | Bayer Aktiengesellschaft (DE) | 2003-02-05 | — | — | EP | disclosed |
| WO-2001064677-A1 | NOVEL IMIDAZOTRIAZINONES AND THE USE THEREOF | BAYER AKTIENGESELLSCHAFT (DE) | 2001-09-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040097498-A1 | Novel imidazotriazinones and the use thereof | CYP4F3, CYP4F2, CYP3A7 | MME 3558/4885ACE 289/4885CPA1 2578/4885 |
| US-20050267112-A1 | Novel imidazotriazinones and the use thereof | CYP3A7, CYP4F2, CYP4F3 | MME 3788/4885ACE 345/4885CPA1 2208/4885 |
| US-20040152693-A1 | Novel substituted 2,3-benzodiazepine derivatives | GABRB2, GABRB3, GABRA2 | MME 4270/4885ACE 3395/4885CPA1 3601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.