Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | GRK2 | P25098 | 1/20 | 0.61 |
| ▸ | PLEC | Q15149 | 1/20 | 0.61 |
| ▸ | APEX1 | P27695 | 2/20 | 0.57 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.57 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.46 |
| ▸ | DUSP5 | Q16690 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29833871 | 1.00 | MEN1 (0.61) | MEN1KMT2APOLBGRK2PLEC | |
| SCHEMBL5859497 | 1.00 | MEN1 (0.61) | MEN1KMT2APOLBGRK2PLEC | |
| SCHEMBL29425680 | 0.91 | ENPP2 (0.61) | MEN1KMT2APOLBGRK2PLEC | |
| SCHEMBL15153906 | 0.91 | ENPP2 (0.61) | MEN1KMT2APOLBGRK2PLEC | |
| SCHEMBL29396086 | 0.90 | MEN1 (0.70) | MEN1KMT2APOLBGRK2PLEC | |
| SCHEMBL7558820 | 0.90 | MEN1 (0.70) | MEN1KMT2APOLBGRK2PLEC | |
| SCHEMBL29702572 | 0.89 | USP2 (0.62) | MEN1KMT2APOLBGRK2PLEC | |
| SCHEMBL11791648 | 0.86 | MEN1 (0.66) | MEN1KMT2APOLBGRK2PLEC | |
| SCHEMBL11791659 | 0.86 | MEN1 (0.66) | MEN1KMT2APOLBGRK2PLEC | |
| SCHEMBL5859446 | 0.86 | POLB (0.66) | MEN1KMT2APOLBGRK2PLEC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 211 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106198508-B | A kind of method for detecting the pesticide containing heavy metal classes | 中国科学院大连化学物理研究所 | 2018-06-26 | — | — | CN | claimed |
| CN-108130076-A | A kind of dry combustion method preparation method of transient metal doped carbon fluorescence quantum | 中国科学院大连化学物理研究所 | 2018-06-08 | — | — | CN | claimed |
| CN-108132244-A | Cu in a kind of drinking water2+、Fe2+With detection method while free chlorine residual | 中国科学院大连化学物理研究所 | 2018-06-08 | — | — | CN | claimed |
| CN-108132246-A | A kind of method that copper ion in water is quickly detected using photochemistry colorimetric method | 中国科学院大连化学物理研究所 | 2018-06-08 | — | — | CN | claimed |
| EP-2785866-B1 | METHOD FOR THE DETECTION OF NUCLEIC ACID SYNTHESIS AND/OR AMPLIFICATION | GENEFAST S R L (IT) | 2017-10-18 | — | — | EP | claimed |
| CN-106198508-A | A kind of high sensitivity quickly detects the method containing heavy metal class pesticide | 中国科学院大连化学物理研究所 | 2016-12-07 | — | — | CN | claimed |
| CN-106147760-A | A kind of preparation method of transient metal doped carbon fluorescence quantum | 中国科学院大连化学物理研究所 | 2016-11-23 | — | — | CN | claimed |
| US-20140329232-A1 | METHOD FOR THE DETECTION OF NUCLEIC ACID SYNTHESIS AND/OR AMPLIFICATION | GENEFAST S.R.L. (IT) | 2014-11-06 | — | — | US | claimed |
| EP-2785866-A1 | METHOD FOR THE DETECTION OF NUCLEIC ACID SYNTHESIS AND/OR AMPLIFICATION | Genefast S.r.l. (IT) | 2014-10-08 | — | — | EP | claimed |
| WO-2013080154-A1 | METHOD FOR THE DETECTION OF NUCLEIC ACID SYNTHESIS AND/OR AMPLIFICATION | GENEFAST S.R.L. (IT) | 2013-06-06 | — | — | WO | claimed |
| EP-1465671-A1 | HYDROGEN PEROXIDE AND PERACETIC ACID INDICATORS AND METHODS USING THE SAME | 3M Innovative Properties Company (US) | 2004-10-13 | — | — | EP | claimed |
| US-20040152760-A1 | Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases | PROTAMED, INC. | 2004-08-05 | — | — | US | claimed |
| JP-2003532634-A | — | — | 2003-11-05 | — | — | JP | claimed |
| US-20030194346-A1 | Hydrogen peroxide and peracetic acid indicators and methods | 3M INNOVATIVE PROPERTIES COMPANY | 2003-10-16 | — | — | US | claimed |
| WO-2003057262-A1 | HYDROGEN PEROXIDE AND PERACETIC ACID INDICATORS AND METHODS USING THE SAME | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2003-07-17 | — | — | WO | claimed |
| WO-2003016615-A1 | SINGLE BATH PROCESS FOR BLEACHING AND DYEING TEXTILES | NOVOZYMES NORTH AMERICA, INC. (US) | 2003-02-27 | — | — | WO | claimed |
| EP-1244435-A2 | POLYHYDROXYLATED AROMATIC COMPOUNDS FOR THE TREATMENT OF AMYLOIDOSIS AND $g(a)-SYNUCLEIN FIBRIL DISEASES | Proteotech Inc. (US) | 2002-10-02 | — | — | EP | claimed |
| US-20010047032-A1 | Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases | PROTAMED, INC. | 2001-11-29 | — | — | US | claimed |
| WO-2001049281-A2 | POLYHYDROXYLATED AROMATIC COMPOUNDS FOR THE TREATMENT OF AMYLOIDOSIS AND α-SYNUCLEIN FIBRIL DISEASES | PROTEOTECH, INC. (US) | 2001-07-12 | — | — | WO | claimed |
| US-5914806-A | Stable electrophoretic particles for displays | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 1999-06-22 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010047032-A1 | Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases | SNCA, PARK7, HTT | THRB 3240/4885MEN1 4522/4885KMT2A 1935/4885 |
| US-20040152760-A1 | Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases | SNCA, PARK7, HTT | THRB 3240/4885MEN1 4522/4885KMT2A 1935/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.