SCHEMBL607667

SCHEMBL607667

Fc1cc(C(F)(F)F)ccc1Br

nearest known ligand 0.46

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
PDE2A O00408 3/20 0.46
IDO1 P14902 2/20 0.44
MPL P40238 2/20 0.40
TAS2R14 Q9NYV8 1/20 0.39
PTPN5 P54829 1/20 0.39
KDM1A O60341 2/20 0.38
KCNH2 Q12809 2/20 0.38
KDM1B Q8NB78 1/20 0.38
MAPT P10636 1/20 0.38
XBP1 P17861 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
GAA P10253 1/20 0.38
TSHR P16473 1/20 0.37
MAPK1 P28482 1/20 0.37
CES2 O00748 2/20 0.36
PKM P14618 1/20 0.36
DAO P14920 1/20 0.36
TAAR1 Q96RJ0 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29453079 1.00 PDE2A (0.46) PDE2AIDO1MPLTAS2R14PTPN5
SCHEMBL27858715 0.83 KDM1A (0.39) PDE2AKDM1AKCNH2KDM1B
SCHEMBL16046268 0.82 KDM1A (0.36) PDE2AIDO1KDM1AKCNH2KDM1B
SCHEMBL5350038 0.82 KDM1A (0.36) PDE2AIDO1KDM1AKCNH2KDM1B
SCHEMBL29762963 0.81 IDO1 (0.44) PDE2AIDO1MPLTAS2R14PTPN5
SCHEMBL283936 0.81 IDO1 (0.44) PDE2AIDO1MPLTAS2R14PTPN5
SCHEMBL31082039 0.80 PDE2A (0.41) PDE2AIDO1MPLPTPN5KDM1A
SCHEMBL7863398 0.80 PTPN5 (0.41) TAS2R14PTPN5MAPTXBP1NPSR1
SCHEMBL29637726 0.80 PTPN5 (0.41) TAS2R14PTPN5MAPTXBP1NPSR1
SCHEMBL1104683 0.79 ALDH1A1 (0.41) KDM1AKCNH2KDM1BMAPTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 477 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3543319-A1 METHOD OF MARKING HYDROCARBON LIQUIDS Johnson Matthey Public Limited Company (GB) 2019-09-25 EP claimed
US-20140120626-A1 METHOD OF MARKING HYDROCARBON LIQUIDS JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) 2014-05-01 US claimed
EP-2707465-A1 METHOD OF MARKING HYDROCARBON LIQUIDS Johnson Matthey Public Limited Company (GB) 2014-03-19 EP claimed
WO-2012153132-A1 METHOD OF MARKING HYDROCARBON LIQUIDS JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) 2012-11-15 WO claimed
US-20260130893-A1 PRMT5 INHIBITORS AND USES THEREOF GILEAD SCIENCES INC (US) 2026-05-14 US disclosed
US-20260124197-A1 NOVEL HETEROBICYCLIC COMPOUND FOR INHIBITING YAP-TEAD INTERACTION AND PHARMACEUTICAL COMPOSITION COMPRISING SAME HANMI PHARMACEUTICAL CO LTD (KR) 2026-05-07 US disclosed
WO-2026089992-A1 PRMT5 INHIBITORS AND USES THEREOF GILEAD SCIENCES, INC. (US) 2026-04-30 WO disclosed
US-12577257-B2 Heterocyclic compounds HOFFMANN-LA ROCHE INC. (US) 2026-03-17 US disclosed
US-20260022130-A1 HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS HOFFMANN-LA ROCHE INC. (US) 2026-01-22 US disclosed
US-20250388585-A1 PRMT5 INHIBITORS AND USES THEREOF GILEAD SCIENCES INC (US) 2025-12-25 US disclosed
US-20250376484-A1 PRMT5 INHIBITORS AND USES THEREOF GILEAD SCIENCES INC (US) 2025-12-11 US disclosed
US-12492181-B2 Gem-disubstituted piperidine melanocortin subtype-2 receptor (MC2R) antagonists and uses thereof Crinetics Pharmaceuticals, Inc. (US) 2025-12-09 US disclosed
EP-0453503-B1 PHENYL NAPHTHALENES HAVING LIQUID CRYSTALLINE PROPERTIES SECR DEFENCE BRIT (GB) 1995-03-22 EP disclosed
US-5252253-A Phenyl naphthalenes having liquid crystalline properties THE SECRETARY OF STATE FOR DEFENCE IN HER BRITANNIC MAJESTY'S GOVERNMENT OF THE UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND (GB) 1993-10-12 US disclosed
EP-0453503-A1 PHENYL NAPHTHALENES HAVING LIQUID CRYSTALLINE PROPERTIES. SECR DEFENCE BRIT (GB) 1991-10-30 EP disclosed
WO-1990008119-A1 PHENYL NAPHTHALENES HAVING LIQUID CRYSTALLINE PROPERTIES THE SECRETARY OF STATE FOR DEFENCE IN HER BRITANNIC MAJESTY'S GOVERNMENT OF THE UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND (GB) 1990-07-26 WO disclosed
EP-0122693-B1 ANTIFUNGAL DI(AZOLYL)PROPANOL DERIVATIVES IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1987-07-08 EP disclosed
US-4625036-A Antifungal azole compounds IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1986-11-25 US disclosed
EP-0145314-A1 Antifungal triazole compound IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1985-06-19 EP disclosed
EP-0122693-A1 Antifungal di(azolyl)propanol derivatives IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1984-10-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250388585-A1 PRMT5 INHIBITORS AND USES THEREOF PRMT1, PRMT5, PRMT6 PDE2A 1640/4885IDO1 2735/4885MPL 3935/4885
US-20260022130-A1 HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS LIPC, LIPA, LPL PDE2A 1219/4885IDO1 3544/4885MPL 1503/4885
US-20260124197-A1 NOVEL HETEROBICYCLIC COMPOUND FOR INHIBITING YAP-TEAD INTERACTION AND PHARMACEUTICAL COMPOSITION COMPRISING SAME YAP1, RCC1, YES1 PDE2A 3751/4885IDO1 1966/4885MPL 4378/4885
US-20260130893-A1 PRMT5 INHIBITORS AND USES THEREOF PRMT5, PRMT1, PRMT6 PDE2A 2095/4885IDO1 2482/4885MPL 3225/4885
US-20250376484-A1 PRMT5 INHIBITORS AND USES THEREOF PRMT5, PRMT1, PRMT9 PDE2A 895/4885IDO1 2702/4885MPL 2256/4885
US-12492181-B2 Gem-disubstituted piperidine melanocortin subtype-2 receptor (MC2R) antagonists and uses thereof MC1R, MC3R, MC2R PDE2A 1028/4885IDO1 1013/4885MPL 150/4885
US-12577257-B2 Heterocyclic compounds H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CBR1, CBR3 PDE2A 1450/4885IDO1 3471/4885MPL 1745/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.