Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 1.00 |
| ▸ | RAB9A | P51151 | 7/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 5/20 | 1.00 |
| ▸ | MEN1 | O00255 | 4/20 | 1.00 |
| ▸ | HTT | P42858 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.88 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.88 |
| ▸ | LMNA | P02545 | 4/20 | 0.88 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.88 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.88 |
| ▸ | MITF | O75030 | 1/20 | 0.88 |
| ▸ | ALOX12 | P18054 | 9/20 | 0.75 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.75 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.68 |
| ▸ | ADAMTS5 | Q9UNA0 | 3/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | THRB | P10828 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15783174 | 0.94 | RAB9A (1.00) | NPC1RAB9AKMT2AMEN1HTT | |
| SCHEMBL4044936 | 0.90 | NPC1 (0.82) | NPC1RAB9AKMT2AMEN1HTT | |
| SCHEMBL2153027 | 0.90 | NPC1 (1.00) | NPC1RAB9AKMT2AMEN1HTT | |
| SCHEMBL4044460 | 0.89 | NPC1 (0.81) | NPC1RAB9AKMT2AMEN1HTT | |
| SCHEMBL609006 | 0.89 | ADAMTS5 (0.84) | NPC1RAB9AKMT2AMEN1HTT | |
| SCHEMBL1811921 | 0.89 | ADAMTS5 (0.82) | NPC1RAB9AKMT2AMEN1HTT | |
| SCHEMBL609111 | 0.88 | RAB9A (0.82) | NPC1RAB9AKMT2AMEN1HTT | |
| SCHEMBL2153098 | 0.88 | NPC1 (0.80) | NPC1RAB9AKMT2AMEN1HTT | |
| SCHEMBL26242169 | 0.87 | HTT (0.77) | NPC1RAB9AKMT2AMEN1HTT | |
| SCHEMBL27790131 | 0.87 | KDM4E (0.78) | NPC1RAB9AKMT2AMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210198244-A1 | SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2021-07-01 | — | — | US | claimed |
| US-20170334890-A1 | SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2017-11-23 | — | — | US | claimed |
| EP-3137079-A1 | INHIBITORS OF JMJD2C AS ANTICANCER AGENTS | The J. David Gladstone Institutes (US) | 2017-03-08 | — | — | EP | claimed |
| US-20170044107-A1 | Inhibitors of JMJD2C as Anticancer Agents | THE J. DAVID GLADSTONE INSTITUTES | 2017-02-16 | — | — | US | claimed |
| WO-2015167874-A1 | INHIBITORS OF JMJD2C AS ANTICANCER AGENTS | THE J. DAVID GLADSTONE INSTITUTES (US) | 2015-11-05 | — | — | WO | claimed |
| US-20150210674-A1 | SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2015-07-30 | — | — | US | claimed |
| WO-2010068767-A1 | SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2010-06-17 | — | — | WO | claimed |
| US-11701374-B1 | 8-hydroxy quinoline derivatives for enhancing telomerase reverse transcriptase (TERT) expression | SIERRA SCIENCES, INC. (US) | 2023-07-18 | — | — | US | disclosed |
| US-11701374-B1 | 8-hydroxy quinoline derivatives for enhancing telomerase reverse transcriptase (TERT) expression | SIERRA SCIENCES, INC. (US) | 2023-07-18 | — | — | US | disclosed |
| US-20210198244-A1 | SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2021-07-01 | — | — | US | disclosed |
| US-10745390-B2 | Small molecule activators of mitochondrial function | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2020-08-18 | — | — | US | disclosed |
| US-20170334890-A1 | SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2017-11-23 | — | — | US | disclosed |
| US-9695157-B2 | Small molecule activators of mitochondrial function | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2017-07-04 | — | — | US | disclosed |
| US-20150210674-A1 | SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2015-07-30 | — | — | US | disclosed |
| US-9000009-B2 | Small molecule activators of mitochondrial function | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2015-04-07 | — | — | US | disclosed |
| US-20120295890-A1 | GLYCOSAMINOGLYCAN INHIBITORS | Zacharon Pharmaceutical, Inc. (US) | 2012-11-22 | — | — | US | disclosed |
| US-20120041023-A1 | SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-02-16 | — | — | US | disclosed |
| WO-2011082175-A2 | GLYCOSAMINOGLYCAN INHIBITORS | ZACHARON PHARMACEUTICALS, INC. (US) | 2011-07-07 | — | — | WO | disclosed |
| WO-2010068767-A1 | SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2010-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150210674-A1 | SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION | TFAM, TFB2M, GFM1 | NPC1 1257/4885RAB9A 1259/4885KMT2A 3433/4885 |
| US-20120295890-A1 | GLYCOSAMINOGLYCAN INHIBITORS | CSGALNACT1, FUT5, ST3GAL3 | NPC1 1684/4885RAB9A 4336/4885KMT2A 4294/4885 |
| US-11701374-B1 | 8-hydroxy quinoline derivatives for enhancing telomerase reverse transcriptase (TERT) expression | TERT, TERF2, RNGTT | NPC1 3227/4885RAB9A 2175/4885KMT2A 280/4885 |
| US-20170044107-A1 | Inhibitors of JMJD2C as Anticancer Agents | KDM2A, KDM1B, KDM5C | NPC1 3394/4885RAB9A 2430/4885KMT2A 24/4885 |
| US-20170334890-A1 | SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION | TFAM, TFB2M, GFM1 | NPC1 1257/4885RAB9A 1259/4885KMT2A 3433/4885 |
| US-20120041023-A1 | SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION | TFAM, TFB2M, GFM1 | NPC1 1267/4885RAB9A 1391/4885KMT2A 3504/4885 |
| US-10745390-B2 | Small molecule activators of mitochondrial function | TFAM, TFB2M, GFM1 | NPC1 1257/4885RAB9A 1259/4885KMT2A 3433/4885 |
| US-20210198244-A1 | SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION | TFAM, TFB2M, GFM1 | NPC1 1257/4885RAB9A 1259/4885KMT2A 3433/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.