SCHEMBL6131838

SCHEMBL6131838

COc1cc(Br)c(CN2CCN(c3ccccn3)CC2)cc1O.[H-].[Na+]

nearest known ligand 0.56

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOD2 known ✓ Q9HC29 1/20 0.50
DRD2 P14416 1/20 0.56
ALDH1A1 P00352 9/20 0.54
KDM4E B2RXH2 8/20 0.54
LMNA P02545 5/20 0.53
SMN1; SMN2 Q16637 4/20 0.53
MAPK1 P28482 3/20 0.53
HTT P42858 3/20 0.53
MAPT P10636 3/20 0.53
RAB9A P51151 3/20 0.53
TDP1 Q9NUW8 3/20 0.53
HSD17B10 Q99714 3/20 0.53
TP53 P04637 1/20 0.53
PAX8 Q06710 1/20 0.53
KLF5 Q13887 1/20 0.53
TSHR P16473 2/20 0.52
KMT2A Q03164 3/20 0.50
NPSR1 Q6W5P4 2/20 0.50
USP2 O75604 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6131961 0.98 DRD2 (0.58) DRD2ALDH1A1KDM4ELMNASMN1; SMN2
SCHEMBL6131770 0.94 ALDH1A1 (0.56) DRD2ALDH1A1KDM4ELMNASMN1; SMN2
Hydrochloric Acid SCHEMBL6131976 0.87 DRD2 (0.58) DRD2ALDH1A1KDM4ELMNASMN1; SMN2
SCHEMBL6131809 0.85 DRD2 (0.61) DRD2ALDH1A1KDM4ELMNASMN1; SMN2
Hydrochloric Acid SCHEMBL7682482 0.84 DRD2 (0.60) DRD2ALDH1A1KDM4ELMNASMN1; SMN2
SCHEMBL6131842 0.84 ALDH1A1 (0.69) ALDH1A1KDM4ELMNASMN1; SMN2MAPK1
SCHEMBL6131825 0.83 DRD2 (0.58) DRD2ALDH1A1KDM4ELMNASMN1; SMN2
SCHEMBL6131921 0.82 ALDH1A1 (0.53) DRD2ALDH1A1KDM4ELMNASMN1; SMN2
SCHEMBL6131821 0.82 ALDH1A1 (0.71) ALDH1A1KDM4ELMNASMN1; SMN2MAPK1
SCHEMBL7686968 0.81 ALDH1A1 (0.54) ALDH1A1KDM4ELMNASMN1; SMN2MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1032559-A4 AMINOALKYLPHENOL DERIVATIVES AND RELATED COMPOUNDS AVENTIS PHARMA INC (US) 2005-05-25 EP disclosed
EP-1032559-A1 AMINOALKYLPHENOL DERIVATIVES AND RELATED COMPOUNDS AVENTIS PHARMACEUTICALS INC. (US) 2000-09-06 EP disclosed
WO-1999016746-A1 AMINOALKYLPHENOL DERIVATIVES AND RELATED COMPOUNDS AVENTIS PHARMACEUTICALS INC. (US) 1999-04-08 WO disclosed