Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 1/20 | 0.62 |
| ▸ | STAT1 | P42224 | 1/20 | 0.62 |
| ▸ | TOP1 | P11387 | 4/20 | 0.44 |
| ▸ | CYCS | P99999 | 4/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | TERT | O14746 | 5/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL455573 | 0.90 | STAT3 (0.67) | STAT3STAT1TOP1CYCSENPP2 | |
| SCHEMBL8977875 | 0.86 | STAT3 (0.69) | STAT3STAT1TOP1CYCSENPP2 | |
| SCHEMBL29585686 | 0.86 | STAT3 (0.83) | STAT3STAT1TOP1CYCSENPP2 | |
| SCHEMBL226835 | 0.86 | STAT3 (0.83) | STAT3STAT1TOP1CYCSENPP2 | |
| SCHEMBL1224432 | 0.82 | STAT3 (0.86) | STAT3STAT1TOP1CYCSENPP2 | |
| SCHEMBL31550992 | 0.82 | STAT3 (0.86) | STAT3STAT1TOP1CYCSENPP2 | |
| SCHEMBL30293296 | 0.82 | STAT3 (0.86) | STAT3STAT1TOP1CYCSENPP2 | |
| SCHEMBL30753635 | 0.82 | STAT3 (0.86) | STAT3STAT1TOP1CYCSENPP2 | |
| SCHEMBL473158 | 0.82 | STAT3 (0.86) | STAT3STAT1TOP1CYCSENPP2 | |
| SCHEMBL2563180 | 0.82 | STAT3 (0.91) | STAT3STAT1TOP1CYCSENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6960644-B2 | Water-soluble block copolymer and production method therefor | KAWAMURA INSTITUTE OF CHEMICAL RESEARCH (JP) | 2005-11-01 | — | — | US | disclosed |
| EP-1400555-A1 | Water-soluble block copolymer and production method therefor | KAWAMURA INSTITUTE OF CHEMICAL RESEARCH (JP) | 2004-03-24 | — | — | EP | disclosed |
| US-20040054127-A1 | Water-soluble block copolymer and production method therefor | KAWAMURA INSTITUTE OF CHEMICAL RESEARCH (JP) | 2004-03-18 | — | — | US | disclosed |