SCHEMBL6300707

SCHEMBL6300707

CCCC(Nc1nc(NCCO)nc(NC(CCC)C2CC(C)(C)N(OC3CCCCC3O)C(C)(C)C2)n1)C1CC(C)(C)N(OC2CCCCC2O)C(C)(C)C1

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HRH4 Q9H3N8 2/20 0.33
GBA1 P04062 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL78005 0.88 CDK1 (0.33) HRH4GBA1
SCHEMBL9428557 0.84 KMT2A (0.37) HRH4GBA1
SCHEMBL9427844 0.83 GBA1 (0.35) HRH4GBA1
SCHEMBL9428450 0.81 KMT2A (0.37) GBA1
SCHEMBL9429379 0.80 KMT2A (0.41) HRH4GBA1
SCHEMBL9207772 0.79 ADAMTS5 (0.33) HRH4
SCHEMBL9428379 0.79 KMT2A (0.40) HRH4GBA1
SCHEMBL456566 0.79 ALDH1A1 (0.31) HRH4GBA1
SCHEMBL9428700 0.79 KMT2A (0.40) HRH4GBA1
SCHEMBL6300713 0.78 KMT2A (0.34) GBA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6391949-B1 None US disclosed
US-6872832-B2 Hydroxy substituted N-alkoxy hindered amines and compositions stabilized therewith CIBA SPECIALTY CHEMICALS CORPORATION (US) 2005-03-29 US disclosed
US-6638997-B2 Used for stabilizing polyolefin and automotive coating formulation against the deleterious effects of oxidative, thermal and actinic radiation CIBA SPECIALTY CHEMICALS CORPORATION 2003-10-28 US disclosed
US-6586507-B2 For stabilizing polyolefins, especially thermoplastic polyolefins, against the deleterious effects of oxidative, thermal and actinic radiation, also for stabilizing acid catalyzed and ambient cured coatings systems CIBA SPECIALTY CHEMICALS CORPORATION 2003-07-01 US disclosed
US-20030120077-A1 Hydroxy substituted N-alkoxy hindered amines and compositions stabilized therewith GALBO JAMES PETER (US) 2003-06-26 US disclosed
US-6420463-B1 HEAT RESISTANCE, OXIDATION RESISTANCE OR PHOTOSTABILITY CIBA SPECIALTY CHEMICALS CORP. 2002-07-16 US disclosed
US-6420562-B2 OXIDATION, HEAT AND RADIATION RESISTANCE CIBA SPECIALITY CHEMICALS CORPORATION 2002-07-16 US disclosed
US-6392041-B1 OXIDATION, HEAT AND RADIATION RESISTANCE CIBA SPECIALTY CHEMICALS CORPORATION 2002-05-21 US disclosed
US-6391949-B2 FOR AUTOMOBILE FINISHES; HEAT, OXIDATION, RADIATION RESISTANCE CIBA SPECIALTY CHEMICALS CORPORATION 2002-05-21 US disclosed
US-20020058735-A1 Hydroxy-substituted N-alkoxy hindered amines and compositions stabilized therewith GALBO JAMES PETER (US) 2002-05-16 US disclosed
US-6388072-B2 TETRAALKYL SUBSTITUTED PIPERIDINE SUBSTITUTED ON THE N-ATOM WITH O-E-OH GROUP (E= ALKYLENE OR PHENYLENE OR CYCLOALIPHATIC DERIVATIVES) ARE USED FOR STABILIZING POLYOLEFINS AND AUTOMOTIVE COATING AGAINST HEAT, OXIDATION CIBA SPECIALTY CHEMICALS CORPORATION 2002-05-14 US disclosed
US-6380389-B2 FOR POLYOLEFINS AND AUTOMOTIVE COATINGS; LIGHT, HEAT, OXIDATION RESISTANCE CIBA SPECIALTY CHEMICALS CORPORATION 2002-04-30 US disclosed
US-20020040145-A1 Hydroxy-substituted N-alkoxy hindered amines and compositions stabilized therewith GALBO JAMES P (US) 2002-04-04 US disclosed
US-20010031872-A1 Hydroxy-substituted N-Alkoxy hindered amines and compositions stabilized therewith GALBO JAMES P (US) 2001-10-18 US disclosed
US-20010020099-A1 Hydroxy-substituted N-alkoxy hindered amines and compositions stabilized therewith GALBO JAMES P (US) 2001-09-06 US disclosed
US-20010018520-A1 Hydroxy-substituted N-alkoxy hindered amines and compositions stabilized therewith GALBO JAMES P (US) 2001-08-30 US disclosed
US-20010016658-A1 Hydroxy-substituted N-alkoxy hindered amines and compositions stabilized therewith GALBO JAMES P (US) 2001-08-23 US disclosed
US-6271377-B1 Hydroxy-substituted N-alkoxy hindered amines and compositions stabilized therewith CIBA SPECIALTY CHEMICALS CORPORATION 2001-08-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020040145-A1 Hydroxy-substituted N-alkoxy hindered amines and compositions stabilized therewith POLH, OGG1, OGFOD1 HRH4 107/4885GBA1 1032/4885
US-20020058735-A1 Hydroxy-substituted N-alkoxy hindered amines and compositions stabilized therewith OGG1, HAO2, POLH HRH4 132/4885GBA1 1174/4885
US-20010016658-A1 Hydroxy-substituted N-alkoxy hindered amines and compositions stabilized therewith POLH, OGG1, OGFOD1 HRH4 107/4885GBA1 1032/4885
US-20010020099-A1 Hydroxy-substituted N-alkoxy hindered amines and compositions stabilized therewith POLH, OGG1, OGFOD1 HRH4 107/4885GBA1 1032/4885
US-20030120077-A1 Hydroxy substituted N-alkoxy hindered amines and compositions stabilized therewith OGG1, POLH, OGFOD1 HRH4 127/4885GBA1 1174/4885
US-20010018520-A1 Hydroxy-substituted N-alkoxy hindered amines and compositions stabilized therewith POLH, OGG1, OGFOD1 HRH4 107/4885GBA1 1032/4885
US-20010031872-A1 Hydroxy-substituted N-Alkoxy hindered amines and compositions stabilized therewith POLH, OGG1, OGFOD1 HRH4 107/4885GBA1 1032/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.