Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.43 |
| ▸ | HTR1D | P28221 | 3/20 | 0.43 |
| ▸ | HTR1B | P28222 | 3/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 5/20 | 0.42 |
| ▸ | DRD3 | P35462 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD5 | P21918 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6511504 | 0.92 | DRD2 (0.52) | HTR1ADRD3DRD2MMP2MMP13 | |
| SCHEMBL6506073 | 0.90 | LMNA (0.44) | HTR1AHTR1DHTR1BHTR6DRD3 | |
| SCHEMBL6502583 | 0.89 | LMNA (0.48) | HTR6DRD3DRD2DRD1DRD4 | |
| SCHEMBL6500224 | 0.89 | ALDH1A1 (0.50) | HTR1AHTR1DHTR1BHTR6DRD3 | |
| SCHEMBL6510748 | 0.87 | HTR6 (0.46) | HTR6DRD3DRD2HSD11B1MCOLN3 | |
| SCHEMBL6501982 | 0.85 | DRD2 (0.47) | HTR1AHTR1DHTR1BHTR6DRD3 | |
| SCHEMBL6500880 | 0.85 | LMNA (0.51) | PDE4BPDE4DHTR6DRD3DRD2 | |
| SCHEMBL6509242 | 0.84 | MAOB (0.54) | HTR1AHTR1DHTR1BHTR6HSD11B1 | |
| SCHEMBL6504564 | 0.84 | HTR6 (0.54) | HTR1AHTR1DHTR1BCRHBPCRHR2 | |
| SCHEMBL6507562 | 0.83 | MAPT (0.57) | HTR1AHTR1DHTR1BHTR6DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005014578-A1 | PHENYLSULFONYL COMPOUNDS AS ANTIPSYCHOTIC AGENTS | GLAXO GROUP LIMITED (GB) | 2005-02-17 | — | — | WO | claimed |
| WO-2005014578-A1 | PHENYLSULFONYL COMPOUNDS AS ANTIPSYCHOTIC AGENTS | GLAXO GROUP LIMITED (GB) | 2005-02-17 | — | — | WO | disclosed |