SCHEMBL6569435

SCHEMBL6569435

[CH2]C(Cc1cccnc1)c1cccs1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.49
FDPS P14324 1/20 0.43
CYP2A6 P11509 2/20 0.41
CYP2E1 P05181 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2B6 P20813 1/20 0.41
VNN1 O95497 1/20 0.40
LMNA P02545 2/20 0.40
NPSR1 Q6W5P4 2/20 0.40
USP2 O75604 1/20 0.40
GPR55 Q9Y2T6 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2D6 P10635 1/20 0.40
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39
CHRNA7 P36544 2/20 0.39
KDM4E B2RXH2 2/20 0.38
ALDH1A1 P00352 1/20 0.38
CHRNB2 P17787 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6570901 0.80 ALDH1A1 (0.40) TSHRCYP2A6NPC1RAB9AALDH1A1
SCHEMBL2096123 0.71 FDPS (0.51) FDPSCYP2A6LMNANPSR1CYP1A2
SCHEMBL324034 0.71 CYP2C19 (0.48) CYP3A4LMNACYP2D6NPC1RAB9A
SCHEMBL4726907 0.71 FDPS (0.56) FDPSCYP2A6CYP3A4CYP2C9CYP1A2
SCHEMBL5454064 0.70 SIGMAR1 (0.44) FDPSCYP3A4CYP1A2CYP2D6RAB9A
SCHEMBL5460636 0.70 CYP19A1 (0.51) FDPSCYP3A4CYP1A2CYP2D6CHRNA7
SCHEMBL7452986 0.70 CYP2D6 (0.49) FDPSCYP2A6CYP3A4CYP2C9CYP1A2
SCHEMBL22311548 0.68 PKM (0.53) TSHRCYP3A4CYP2C9VNN1LMNA
SCHEMBL8306418 0.68 ADRA1D (0.49) CYP2A6CYP2E1CYP3A4CYP2C9CYP2B6
SCHEMBL2884688 0.67 CHRNA7 (0.52) CYP2A6CYP2E1CYP3A4CYP2C9CYP2B6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1178912-C Small molecule inhibitors of rotamase enzyme activity ������˹ҩƷ��˾ 2004-12-08 CN disclosed
CN-1542001-A Small molecule inhibitors of rotamase enzyme activity GPI����عɹ�˾ 2004-11-03 CN disclosed
EP-1404325-A2 METHOD FOR TREATING NERVE INJURY CAUSED BY SURGERY GUILFORD PHARMACEUTICALS INC. (US) 2004-04-07 EP disclosed
WO-2002096420-A2 METHOD FOR TREATING NERVE INJURY CAUSED BY SURGERY GUILFORD PHARMACEUTICALS INC. (US) 2002-12-05 WO disclosed
CN-1336930-A Bridged heterocyclic derivatives GPINIL HOLDING CORP (US) 2002-02-20 CN disclosed
EP-1127049-A1 BRIDGED HETEROCYCLIC DERIVATIVES GPI NIL Holdings, Inc. (US) 2001-08-29 EP disclosed
EP-1107752-A1 PYRROLIDINE DERIVATIVES FOR VISION AND MEMORY DISORDERS GPI NIL Holdings, Inc. (US) 2001-06-20 EP disclosed
EP-1105112-A2 COMPOSITIONS AND USES FOR VISION AND MEMORY DISORDERS GPI NIL Holdings, Inc. (US) 2001-06-13 EP disclosed
US-6140357-A STIMULATING GROWTH OF DAMAGED PERIPHERAL NERVES BY ADMINISTERING TO DAMAGED PERIPHERAL NERVES NEUROTROPHIC N-GLYOXYLPROLYL ESTER COMPOUNDHAVING AN AFFINITY FOR IMMUNOPHILINS GPI NIL HOLDINGS, INC. (US) 2000-10-31 US disclosed
EP-1011650-A1 METHOD FOR PREVENTING AND TREATING HEARING LOSS USING SENSORINEUROTROPHIC COMPOUNDS Amgen Inc., (US) 2000-06-28 EP disclosed
WO-2000009124-A1 PYRROLIDINE DERIVATIVES FOR VISION AND MEMORY DISORDERS GPI NIL HOLDINGS, INC. (US) 2000-02-24 WO disclosed
WO-2000009108-A2 COMPOSITIONS AND USES FOR VISION AND MEMORY DISORDERS GPI NIL HOLDINGS, INC. (US) 2000-02-24 WO disclosed
WO-1999014998-A2 METHOD FOR PREVENTING AND TREATING HEARING LOSS USING SENSORINEUROTROPHIC COMPOUNDS AMGEN INC. (US) 1999-04-01 WO disclosed
US-5859031-A Small molecule inhibitors of rotamase enzyme activity GPI NIL HOLDINGS, INC. (US) 1999-01-12 US disclosed
WO-1998055090-A1 HAIR GROWTH COMPOSITIONS AND USES GUILFORD PHARMACEUTICALS INC. (US) 1998-12-10 WO disclosed
WO-1998055091-A1 PYRROLIDINE DERIVATIVE HAIR GROWTH COMPOSITIONS AND USES GUILFORD PHARMACEUTICALS INC. (US) 1998-12-10 WO disclosed
US-5795908-A FKBP IMMUNOPHILINS FOR ENZYME INHIBITORS GPI NIL HOLDINGS, INC. (US) 1998-08-18 US disclosed
CN-1187188-A Small molecule inhibitors of rotamase enzyme activity GUILFORD PHARM INC (US) 1998-07-08 CN disclosed
EP-0769006-A4 GUILFORD PHARM INC (US) 1997-05-28 EP disclosed
EP-0769006-A1 SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY GUILFORD PHARMACEUTICALS INC. (US) 1997-04-23 EP disclosed