Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10498551 | 0.85 | TRPV4 (0.53) | HTR2CHTR2BLMNAHTTTSHR | |
| SCHEMBL9711164 | 0.84 | HTR2C (0.50) | HTR2CHTR2BLMNAHTTTSHR | |
| SCHEMBL10498690 | 0.84 | HTR2C (0.47) | HTR2CHTR2BLMNAHTTTSHR | |
| SCHEMBL11111261 | 0.82 | GAA (0.40) | HTR2CHTR2BLMNAHTTTSHR | |
| SCHEMBL10498475 | 0.82 | HTR2C (0.46) | HTR2CHTR2BLMNAHTTTSHR | |
| SCHEMBL10499442 | 0.82 | HTR2C (0.46) | HTR2CHTR2BLMNAHTTTSHR | |
| SCHEMBL28830227 | 0.81 | ALDH1A1 (0.56) | LMNAHTTTSHRMAPK1L3MBTL1 | |
| SCHEMBL11145869 | 0.79 | MAPT (0.47) | LMNAHTTTSHRS1PR4ALDH1A1 | |
| Water SCHEMBL11430929 | 0.78 | MAPT (0.46) | LMNAHTTTSHRS1PR4ALDH1A1 | |
| SCHEMBL14345658 | 0.76 | HTR2C (0.52) | HTR2CHTR2BLMNAHTTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1286960-B1 | IMPROVED ISOLATION OF PHENYL ESTER SALTS FROM MIXTURES COMPRISING SULFOLANE | EASTMAN CHEM CO (US) | 2004-08-18 | — | — | EP | disclosed |
| EP-1286960-A2 | IMPROVED ISOLATION OF PHENYL ESTER SALTS FROM MIXTURES COMPRISING SULFOLANE | EASTMAN CHEMICAL COMPANY (US) | 2003-03-05 | — | — | EP | disclosed |
| US-6498124-B2 | ADJUSTING THE TEMPERATURE OF A FIRST MIXTURE COMPRISING A PHENYL ESTER SALT AND SULFOLANE TO FORM SECOND MIXTURE; SEPARATING THE SOLID PHENYL ESTER SALT FROM THE SECOND MIXTURE WHILE MAINTAINING THE TEMPERATURE OF THE MIXTURE | EASTMAN CHEMICAL COMPANY | 2002-12-24 | — | — | US | disclosed |
| US-20020040151-A1 | Isolation of phenyl ester salts from mixtures comprising sulfolane | EASTMAN CHEMICAL COMPANY | 2002-04-04 | — | — | US | disclosed |
| WO-2001094303-A2 | IMPROVED ISOLATION OF PHENYL ESTER SALTS FROM MIXTURES COMPRISING SULFOLANE | EASTMAN CHEMICAL COMPANY (US) | 2001-12-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020040151-A1 | Isolation of phenyl ester salts from mixtures comprising sulfolane | SULT1E1, SULT1A1, STS | HTR2C 1247/4885HTR2B 2011/4885LMNA 4832/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.