Eflucimibe

Eflucimibe

SCHEMBL668292

CCCCCCCCCCCCS[C@H](C(=O)Nc1cc(C)c(O)c(C)c1C)c1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SOAT2 O75908 1/20 1.00
ACAT1 P24752 1/20 1.00
SOAT1 P35610 1/20 1.00
ALDH1A1 P00352 5/20 0.43
CYP2C9 P11712 2/20 0.43
CYP2C19 P33261 2/20 0.43
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
LMNA P02545 4/20 0.39
PAX8 Q06710 1/20 0.39
NAAA Q02083 2/20 0.39
MAPT P10636 7/20 0.39
NPSR1 Q6W5P4 2/20 0.38
KMT2A Q03164 4/20 0.38
MEN1 O00255 3/20 0.38
PLK1 P53350 1/20 0.37
CYSLTR2 Q9NS75 1/20 0.36
CYSLTR1 Q9Y271 1/20 0.36
CYP2D6 P10635 1/20 0.36
POLB P06746 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Eflucimibe SCHEMBL668294 1.00 SOAT2 (1.00) SOAT2ACAT1SOAT1ALDH1A1CYP2C9
Eflucimibe SCHEMBL29427708 1.00 SOAT2 (1.00) SOAT2ACAT1SOAT1ALDH1A1CYP2C9
Eflucimibe SCHEMBL8041449 0.91 SOAT2 (0.82) SOAT2ACAT1SOAT1ALDH1A1CYP2C9
SCHEMBL5900907 0.89 SOAT2 (0.80) SOAT2ACAT1SOAT1ALDH1A1CYP2C9
SCHEMBL5900910 0.89 SOAT2 (0.80) SOAT2ACAT1SOAT1ALDH1A1CYP2C9
SCHEMBL8079670 0.89 SOAT1 (0.79) SOAT2ACAT1SOAT1ALDH1A1CYP2C9
SCHEMBL8416087 0.88 SOAT2 (0.78) SOAT2ACAT1SOAT1ALDH1A1CYP2C9
SCHEMBL13269963 0.87 SOAT2 (0.76) SOAT2ACAT1SOAT1ALDH1A1CYP2C9
SCHEMBL13193425 0.86 SOAT2 (0.75) SOAT2ACAT1SOAT1ALDH1A1CYP2C9
SCHEMBL13249165 0.85 SOAT2 (0.73) SOAT2ACAT1SOAT1ALDH1A1CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 310 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026087680-A1 TREATMENT FOR CARDIOVASCULAR DISEASE SAPREME TECHNOLOGIES B.V. (NL) 2026-04-30 WO claimed
US-20260091010-A1 COMPOSITIONS AND METHODS FOR MANAGING REBOUND OF BODY WEIGHT AND METABOLIC PARAMETERS EFIL BIOSCIENCE INC (KR) 2026-04-02 US claimed
US-12419847-B2 Composition and method for attenuating neuroinflammation, amyloidopathy and tauopathy TRUSTEES OF DARTMOUTH COLLEGE (US) 2025-09-23 US claimed
WO-2024098005-A1 COMPOSITION COMPRISING GLP-1 RECEPTOR AGONIST AND ACAT INHIBITOR EFIL BioScience Inc. (KR) 2024-05-10 WO claimed
US-20240148833-A1 COMPOSITION COMPRISING GLP-1 RECEPTOR AGONIST AND ACAT INHIBITOR EFIL BioScience Inc. (KR) 2024-05-09 US claimed
US-11911469-B2 Combination of ACAT1 inhibitor and checkpoint antibody for treating cancer Center for Excellence in Molecular Cell Science, Chinese Academy of Scienes (CN) 2024-02-27 US claimed
WO-2023183843-A1 COMBINATION THERAPY FOR TREATING CASTRATION-RESISTANT PROSTATE CANCER PURDUE RESEARCH FOUNDATION (US) 2023-09-28 WO claimed
US-20230302021-A1 COMPOSITIONS AND METHODS FOR TREATING CASTRATION-RESISTANT PROSTATE CANCER PURDUE RESEARCH FOUNDATION 2023-09-28 US claimed
US-20230285333-A1 COMPOSITIONS AND METHODS FOR CONTROLLING FOOD INTAKE OF ANIMAL PURDUE RESEARCH FOUNDATION 2023-09-14 US claimed
US-20230270702-A1 COMPOSITIONS AND METHODS FOR TREATING HYPEPHAGIA PURDUE RESEARCH FOUNDATION 2023-08-31 US claimed
WO-2018057834-A1 COMBINATORY TREATMENT STRATEGIES OF CANCER BASED ON RNA POLYMERASE I INHIBITION THE JOHNS HOPKINS UNIVERSITY (US) 2018-03-29 WO claimed
EP-1434567-B1 METHOD FOR PREPARING A COMPOUND FOR INTERACTION OF ACTIVE SUBSTANCES WITH A POROUS SUPPORT USING SUPERCRITICAL FLUID PF MEDICAMENT (FR) 2007-12-19 EP claimed
US-20050274671-A1 Method for preparing a compound of interaction of active substances with a porous support using supercritical fluid PIERRE FABRE MEDICAMENT (FR) 2005-12-15 US claimed
US-20050192245-A1 Medicinal composition for treating arteriosclerosis SANKYO COMPANY, LIMITED (JP) 2005-09-01 US claimed
EP-1555032-A1 MEDICINAL COMPOSITION FOR TREATING ARTERIOSCLEROSIS Sankyo Company, Limited (JP) 2005-07-20 EP claimed
US-6864246-B2 Anilide and cyclodextrin complexes, their preparation and their use as medicine in particular for treating dyslipidemiae PIERRE FABRE MEDICAMENT (FR) 2005-03-08 US claimed
EP-1434567-A1 METHOD FOR PREPARING A COMPOUND FOR INTERACTION OF ACTIVE SUBSTANCES WITH A POROUS SUPPORT USING SUPERCRITICAL FLUID PIERRE FABRE MEDICAMENT (FR) 2004-07-07 EP claimed
US-20040127462-A1 Anilide and cyclodextrin complexes, their preparation and their use as medicine in particular for treating dyslipidemiae PIERRE FABRE MEDICAMENT (FR) 2004-07-01 US claimed
WO-2003043604-A1 METHOD FOR PREPARING A COMPOUND FOR INTERACTION OF ACTIVE SUBSTANCES WITH A POROUS SUPPORT USING SUPERCRITICAL FLUID PIERRE FABRE MEDICAMENT (FR) 2003-05-30 WO claimed
WO-2003030867-A2 METHOD FOR PREPARING AN INTERACTIVE COMPOUND OF AN ANILIDE DERIVATIVE WITH A POROUS SUPPORT BY SUPERCRITICAL FLUID PIERRE FABRE MEDICAMENT (FR) 2003-04-17 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11911469-B2 Combination of ACAT1 inhibitor and checkpoint antibody for treating cancer CD274, PDCD1, PDCD4 SOAT2 3131/4885ACAT1 7/4885SOAT1 1835/4885
US-12419847-B2 Composition and method for attenuating neuroinflammation, amyloidopathy and tauopathy MAPT, LCAT, ACAT2 SOAT2 33/4885ACAT1 4/4885SOAT1 74/4885
US-20230270702-A1 COMPOSITIONS AND METHODS FOR TREATING HYPEPHAGIA ACAT2, ACAT1, LCAT SOAT2 33/4885ACAT1 2/4885SOAT1 44/4885
US-20230285333-A1 COMPOSITIONS AND METHODS FOR CONTROLLING FOOD INTAKE OF ANIMAL ACAT2, ACAT1, LCAT SOAT2 17/4885ACAT1 2/4885SOAT1 15/4885
US-20040127462-A1 Anilide and cyclodextrin complexes, their preparation and their use as medicine in particular for treating dyslipidemiae APOB, HDLBP, PCSK9 SOAT2 38/4885ACAT1 458/4885SOAT1 82/4885
US-20260091010-A1 COMPOSITIONS AND METHODS FOR MANAGING REBOUND OF BODY WEIGHT AND METABOLIC PARAMETERS GLP1R, GPR119, FABP4 SOAT2 220/4885ACAT1 25/4885SOAT1 254/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.