Eflucimibe

Eflucimibe

SCHEMBL668294

CCCCCCCCCCCCSC(C(=O)Nc1cc(C)c(O)c(C)c1C)c1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SOAT2 O75908 1/20 1.00
ACAT1 P24752 1/20 1.00
SOAT1 P35610 1/20 1.00
ALDH1A1 P00352 5/20 0.43
CYP2C9 P11712 2/20 0.43
CYP2C19 P33261 2/20 0.43
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
LMNA P02545 4/20 0.39
PAX8 Q06710 1/20 0.39
NAAA Q02083 2/20 0.39
MAPT P10636 7/20 0.39
NPSR1 Q6W5P4 2/20 0.38
KMT2A Q03164 4/20 0.38
MEN1 O00255 3/20 0.38
PLK1 P53350 1/20 0.37
CYSLTR2 Q9NS75 1/20 0.36
CYSLTR1 Q9Y271 1/20 0.36
CYP2D6 P10635 1/20 0.36
POLB P06746 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Eflucimibe SCHEMBL668292 1.00 SOAT2 (1.00) SOAT2ACAT1SOAT1ALDH1A1CYP2C9
Eflucimibe SCHEMBL29427708 1.00 SOAT2 (1.00) SOAT2ACAT1SOAT1ALDH1A1CYP2C9
Eflucimibe SCHEMBL8041449 0.91 SOAT2 (0.82) SOAT2ACAT1SOAT1ALDH1A1CYP2C9
SCHEMBL5900907 0.89 SOAT2 (0.80) SOAT2ACAT1SOAT1ALDH1A1CYP2C9
SCHEMBL5900910 0.89 SOAT2 (0.80) SOAT2ACAT1SOAT1ALDH1A1CYP2C9
SCHEMBL8079670 0.89 SOAT1 (0.79) SOAT2ACAT1SOAT1ALDH1A1CYP2C9
SCHEMBL8416087 0.88 SOAT2 (0.78) SOAT2ACAT1SOAT1ALDH1A1CYP2C9
SCHEMBL13269963 0.87 SOAT2 (0.76) SOAT2ACAT1SOAT1ALDH1A1CYP2C9
SCHEMBL13193425 0.86 SOAT2 (0.75) SOAT2ACAT1SOAT1ALDH1A1CYP2C9
SCHEMBL13249165 0.85 SOAT2 (0.73) SOAT2ACAT1SOAT1ALDH1A1CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190247397-A1 COMBINATORY TREATMENT STRATEGIES OF CANCER BASED ON RNA POLYMERASE I INHIBITION THE JOHNS HOPKINS UNIVERSITY 2019-08-15 US claimed
EP-3515448-A1 COMBINATORY TREATMENT STRATEGIES OF CANCER BASED ON RNA POLYMERASE I INHIBITION The Johns Hopkins University (US) 2019-07-31 EP claimed
WO-2018057834-A1 COMBINATORY TREATMENT STRATEGIES OF CANCER BASED ON RNA POLYMERASE I INHIBITION THE JOHNS HOPKINS UNIVERSITY (US) 2018-03-29 WO claimed
US-20050192245-A1 Medicinal composition for treating arteriosclerosis SANKYO COMPANY, LIMITED (JP) 2005-09-01 US claimed
EP-1555032-A1 MEDICINAL COMPOSITION FOR TREATING ARTERIOSCLEROSIS Sankyo Company, Limited (JP) 2005-07-20 EP claimed
US-12303508-B2 Combinatory treatment strategies of cancer based on RNA polymerase I inhibition THE JOHNS HOPKINS UNIVERSITY (US) 2025-05-20 US disclosed
US-11911469-B2 Combination of ACAT1 inhibitor and checkpoint antibody for treating cancer Center for Excellence in Molecular Cell Science, Chinese Academy of Scienes (CN) 2024-02-27 US disclosed
EP-3515448-B1 COMBINATORY TREATMENT STRATEGIES OF CANCER BASED ON RNA POLYMERASE I INHIBITION UNIV JOHNS HOPKINS (US) 2023-07-05 EP disclosed
US-11571400-B2 ACAT1 inhibitors for treating cancer CENTER FOR EXCELLENCE IN MOLECULAR CELL SCIENCE, CHINESE ACADEMY OF SCIENCES (CN) 2023-02-07 US disclosed
US-10925885-B2 Thyromimetics for the treatment of fatty liver diseases METABASIS THERAPEUTICS, INC. (US) 2021-02-23 US disclosed
US-10420781-B2 Thyroid hormone receptor agonist and use thereof METABASIS THERAPEUTICS INC. (US) 2019-09-24 US disclosed
US-20190247397-A1 COMBINATORY TREATMENT STRATEGIES OF CANCER BASED ON RNA POLYMERASE I INHIBITION THE JOHNS HOPKINS UNIVERSITY 2019-08-15 US disclosed
WO-2004035552-A1 ALPHA-PHENYL ACETANILIDE DERIVATIVES HAVING AN ACAT INHIBITING ACTIVITY AND THE THERAPEUTIC APPLICATION THEREOF PIERRE FABRE MEDICAMENT (FR) 2004-04-29 WO disclosed
EP-1377545-A1 ANILIDE AND CYCLODEXTRIN COMPLEXES, THEIR PREPARATION AND THEIR USE AS MEDICINE IN PARTICULAR FOR TREATING DYSLIPIDEMIAE PIERRE FABRE MEDICAMENT (FR) 2004-01-07 EP disclosed
EP-1377545-A1 ANILIDE AND CYCLODEXTRIN COMPLEXES, THEIR PREPARATION AND THEIR USE AS MEDICINE IN PARTICULAR FOR TREATING DYSLIPIDEMIAE PIERRE FABRE MEDICAMENT (FR) 2004-01-07 EP disclosed
WO-2003106435-A1 FUSED-RING PYRIMIDIN-4(3H)-ONE DERIVATIVES, PROCESSES FOR THE PREPARATION AND USES THEREOF SANKYO COMPANY, LIMITED (JP) 2003-12-24 WO disclosed
WO-2002083632-A1 ANILIDE AND CYCLODEXTRIN COMPLEXES, THEIR PREPARATION AND THEIR USE AS MEDICINE IN PARTICULAR FOR TREATING DYSLIPIDEMIAE PIERRE FABRE MEDICAMENT (FR) 2002-10-24 WO disclosed
WO-2002083632-A1 ANILIDE AND CYCLODEXTRIN COMPLEXES, THEIR PREPARATION AND THEIR USE AS MEDICINE IN PARTICULAR FOR TREATING DYSLIPIDEMIAE PIERRE FABRE MEDICAMENT (FR) 2002-10-24 WO disclosed
EP-0874812-B1 NOVEL 2,3,5-TRIMETHYL-4-HYDROXY ANILIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTICAL USE THEREOF PF MEDICAMENT (FR) 2000-04-05 EP disclosed
US-5990173-A ANTICHOLESTEROL AGENTS; TREATING ATHEROSCLEROSIS; ENZYME INHIBITORS OF ACYLCOENZYME A:CHOLESTEROL ACYLTRANSFERASE (ACAT) PIERRE FABRE MEDICAMENT (FR) 1999-11-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10420781-B2 Thyroid hormone receptor agonist and use thereof THRB, THRA, TSHR SOAT2 533/4885ACAT1 781/4885SOAT1 384/4885
US-10925885-B2 Thyromimetics for the treatment of fatty liver diseases TSHR, THRA, FABP1 SOAT2 426/4885ACAT1 210/4885SOAT1 463/4885
US-11571400-B2 ACAT1 inhibitors for treating cancer ACAT2, ACAT1, CEPT1 SOAT2 384/4885ACAT1 2/4885SOAT1 149/4885
US-11911469-B2 Combination of ACAT1 inhibitor and checkpoint antibody for treating cancer CD274, PDCD1, PDCD4 SOAT2 3131/4885ACAT1 7/4885SOAT1 1835/4885
US-12303508-B2 Combinatory treatment strategies of cancer based on RNA polymerase I inhibition ACAT1, PARP1, POLRMT SOAT2 524/4885ACAT1 1/4885SOAT1 238/4885
US-20190247397-A1 COMBINATORY TREATMENT STRATEGIES OF CANCER BASED ON RNA POLYMERASE I INHIBITION ACAT1, PARP1, POLRMT SOAT2 524/4885ACAT1 1/4885SOAT1 238/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.