SCHEMBL67628

SCHEMBL67628

O=Cc1ccc(F)c(C(F)(F)F)c1

nearest known ligand 0.58

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 1/20 0.58
ALDH1A1 P00352 2/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
AR P10275 8/20 0.39
KDM4E B2RXH2 1/20 0.39
PTGS2 P35354 1/20 0.39
RAB9A P51151 1/20 0.39
SLC22A12 Q96S37 1/20 0.38
HSD17B10 Q99714 1/20 0.38
AKR1C3 P42330 1/20 0.37
AKR1C2 P52895 1/20 0.37
APP P05067 1/20 0.37
MPL P40238 1/20 0.37
KMO O15229 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10299815 1.00 KIF11 (0.58) KIF11ALDH1A1SMN1; SMN2ARKDM4E
SCHEMBL18002827 0.88 KIF11 (0.47) KIF11ALDH1A1SLC22A12APP
SCHEMBL30679640 0.85 KIF11 (0.75) KIF11ARAKR1C3AKR1C2MPL
SCHEMBL29438427 0.83 KIF11 (0.73) KIF11ALDH1A1SMN1; SMN2KDM4EPTGS2
SCHEMBL48409 0.83 KIF11 (0.73) KIF11ALDH1A1SMN1; SMN2KDM4EPTGS2
SCHEMBL472408 0.83 KIF11 (0.56) KIF11ALDH1A1KDM4EPTGS2RAB9A
SCHEMBL17508145 0.82 KIF11 (0.53) KIF11AR
SCHEMBL18002564 0.82 AHR (0.49) KIF11ARSLC22A12HSD17B10APP
SCHEMBL13496965 0.82 PTGS2 (0.43) KIF11ALDH1A1SMN1; SMN2KDM4EPTGS2
SCHEMBL21996031 0.81 XDH (0.46) KIF11ALDH1A1ARKDM4ESLC22A12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 579 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119431706-A Fatigue-resistant polyurethane elastomer and preparation method and application thereof 万勋科技(深圳)有限公司 2025-02-14 CN claimed
CN-115637020-A Hyperbranched epoxy resin thermosetting resin composition and application thereof 复旦大学 2023-01-24 CN claimed
CN-107188851-B Method for synthesizing astemizole key intermediate and derivative thereof 湖南大学 2020-04-07 CN claimed
US-9707510-B2 Regenerable solvent mixtures for acid-gas separation RESEARCH TRIANGLE INSTITUTE (US) 2017-07-18 US claimed
EP-2611519-A2 REGENERABLE SOLVENT MIXTURES WITH NITROGENOUS BASE FOR ACID-GAS SEPARATION Research Triangle Institute (US) 2013-07-10 EP claimed
US-20130164200-A1 REGENERABLE SOLVENT MIXTURES FOR ACID-GAS SEPARATION RESEARCH TRIANGLE INSTITUTE (US) 2013-06-27 US claimed
WO-2012031281-A2 REGENERABLE SOLVENT MIXTURES FOR ACID-GAS SEPARATION RESEARCH TRIANGLE INSTITUTE (US) 2012-03-08 WO claimed
US-8034936-B2 Spirocyclic cyclohexane compounds useful to treat substance dependency GRUENENTHAL GMBH (DE) 2011-10-11 US claimed
US-20110053970-A1 Spirocyclic Cyclohexane Compounds Useful To Treat Substance Dependency GRUENENTHAL GMBH (DE) 2011-03-03 US claimed
US-20060084176-A1 Detection of uronium salts YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 2006-04-20 US claimed
EP-4702005-A1 CNDP2 MODULATORS AND METHODS FOR THEIR USE Metabolon Inc. (US) 2026-03-04 EP disclosed
EP-4703361-A1 PYRIDAZINONE TRPC4/5 INHIBITOR AND USE THEREOF Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) 2026-03-04 EP disclosed
US-12545683-B2 CBP/catenin signaling pathway inhibitors and uses thereof 3+2 PHARMA, LLC (US) 2026-02-10 US disclosed
US-20260007998-A1 REGENERABLE SOLVENT MIXTURES FOR ACID-GAS SEPARATION RES TRIANGLE INST (US) 2026-01-08 US disclosed
US-12427471-B2 Regenerable solvent mixtures for acid-gas separation RESEARCH TRIANGLE INSTITUTE (NC) 2025-09-30 US disclosed
EP-0396987-B1 Nuclear fluorinated trifluoromethylbenzaldehydes BAYER AG (DE) 1994-06-15 EP disclosed
US-5284647-A Administering for magnetic resonance imaging SCHERING AKTIENGESELLSCHAFT (DE) 1994-02-08 US disclosed
US-5041683-A Nuclear-fluorinated trifluoromethylbenzaldehydes BAYER AKTIENGESELLSCHAFT (DE) 1991-08-20 US disclosed
EP-0396987-A2 Nuclear fluorinated trifluoromethylbenzaldehydes BAYER AG (DE) 1990-11-14 EP disclosed
EP-0336879-A1 Meso-tetraphenylporphyrin complex compounds,process for their preparation and pharmaceuticals containing them SCHERING AKTIENGESELLSCHAFT (DE) 1989-10-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110053970-A1 Spirocyclic Cyclohexane Compounds Useful To Treat Substance Dependency TACR2, OPRK1, OPRD1 KIF11 4104/4885ALDH1A1 89/4885SMN1; SMN2 3086/4885
US-12545683-B2 CBP/catenin signaling pathway inhibitors and uses thereof CREBBP, CREB1, CTNNB1 KIF11 4541/4885ALDH1A1 2182/4885SMN1; SMN2 3429/4885
US-20260007998-A1 REGENERABLE SOLVENT MIXTURES FOR ACID-GAS SEPARATION NOS2, DUOX2, SMOX KIF11 2327/4885ALDH1A1 3356/4885SMN1; SMN2 1262/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.