Ramipril

Ramipril

SCHEMBL678408

CCOC(=O)C(CCc1ccccc1)NC(C)C(=O)N1C(C(=O)O)CC2CCCC21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACE

The experimentally established mechanism targets of Ramipril. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ACE known ✓ P12821 12/20 1.00
MEN1 O00255 2/20 1.00
KMT2A Q03164 2/20 1.00
CYP3A4 P08684 1/20 1.00
ALOX15 P16050 1/20 1.00
LMNA P02545 2/20 0.96
USP2 O75604 1/20 0.96
SMN1; SMN2 Q16637 1/20 0.63
ABCB11 O95342 2/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ramipril SCHEMBL7260219 1.00 ACE (1.00) ACEMEN1KMT2ACYP3A4ALOX15
Ramipril SCHEMBL7912384 1.00 ACE (1.00) ACEMEN1KMT2ACYP3A4ALOX15
Ramipril SCHEMBL13575807 1.00 ACE (1.00) ACEMEN1KMT2ACYP3A4ALOX15
Ramipril SCHEMBL9175613 1.00 ACE (1.00) ACEMEN1KMT2ACYP3A4ALOX15
Ramipril SCHEMBL9327932 1.00 ACE (1.00) ACEMEN1KMT2ACYP3A4ALOX15
Ramipril SCHEMBL8082369 1.00 ACE (1.00) ACEMEN1KMT2ACYP3A4ALOX15
Ramipril SCHEMBL683419 1.00 ACE (1.00) ACEMEN1KMT2ACYP3A4ALOX15
Ramipril SCHEMBL16059 1.00 ACE (1.00) ACEMEN1KMT2ACYP3A4ALOX15
Ramipril SCHEMBL13780690 1.00 ACE (1.00) ACEMEN1KMT2ACYP3A4ALOX15
Ramipril SCHEMBL5983968 1.00 ACE (1.00) ACEMEN1KMT2ACYP3A4ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022083644-A1 BIOSENSING PLATFORM FOR DETECTING VIRAL INFECTIONS AND METHODS FOR SCREENING A MODULATOR OF VIRAL INFECTIONS AND PROTECTING THEREFROM PD BIOMEDICAL CO., LTD. (CN) 2022-04-28 WO disclosed
US-20220117936-A1 BIOSENSING PLATFORM FOR DETECTING VIRAL INFECTIONS AND METHODS FOR SCREENING A MODULATOR OF VIRAL INFECTIONS AND PROTECTING THEREFROM PIN JYE BIO TECH CO., LTD. (TW) 2022-04-21 US disclosed
US-9730949-B2 Angiotensin converting enzyme inhibitors for treating optic neuropathy or congenital optic atrophy REKIK RAOUF (TN) 2017-08-15 US disclosed
US-9730949-B2 Angiotensin converting enzyme inhibitors for treating optic neuropathy or congenital optic atrophy REKIK RAOUF (TN) 2017-08-15 US disclosed
US-20150174146-A1 ANGIOTENSIN CONVERTING ENZYME INHIBITORS FOR TREATING OPTIC NEUROPATHY OR CONGENITAL OPTIC ATROPHY REKIK RAOUF (TN) 2015-06-25 US disclosed
US-20150174146-A1 ANGIOTENSIN CONVERTING ENZYME INHIBITORS FOR TREATING OPTIC NEUROPATHY OR CONGENITAL OPTIC ATROPHY REKIK RAOUF (TN) 2015-06-25 US disclosed
EP-2044010-B1 NEW PHARMACEUTICAL INTERMEDIATES IN THE SYNTHESIS OF ACE-INIHIBITORS AND THE USE THEREOF EGIS GYOGYSZERGYAR NYILVANOSAN MUEKOEDO RESZVENYTARSASAG (HU) 2014-01-08 EP disclosed
US-20110269717-A1 NEUROGENESIS BY MODULATING ANGIOTENSIN BRAINCELLS INC. (US) 2011-11-03 US disclosed
EP-2382975-A2 Neurogenesis by modulating angiotensin Braincells, Inc. (US) 2011-11-02 EP disclosed
EP-2377531-A2 Neurogenesis by modulating angiotensin Braincells, Inc. (US) 2011-10-19 EP disclosed
US-7960558-B2 Pharmaceutical intermediate for synthesizing ACE inhibitors and the use thereof EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAG (HU) 2011-06-14 US disclosed
US-20110092464-A1 NEUROGENESIS BY MODULATING ANGIOTENSIN BRAINCELLS INC. (US) 2011-04-21 US disclosed
US-20110046090-A1 MODULATION OF NEUROGENESIS WITH GABA AGENTS AND GABA ANALOGS BRAINCELLS INC. (US) 2011-02-24 US disclosed
US-7858611-B2 Neurogenesis by modulating angiotensin BRAINCELLS INC. (US) 2010-12-28 US disclosed
US-20100286404-A1 PHARMACEUTICAL INTERMEDIATES IN THE SYNTHESIS OF ACE-INHIBITORS AND THE USE THEREOF EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAG (HU) 2010-11-11 US disclosed
US-20090214652-A1 SOFT TISSUE IMPLANTS AND ANTI-SCARRING AGENTS ANGIOTECH INTERNATIONAL AG (CH) 2009-08-27 US disclosed
US-20080167291-A1 NEUROGENESIS BY MODULATING ANGIOTENSIN BRAINCELLS, INC. (US) 2008-07-10 US disclosed
US-5068351-A PROCESS FOR THE PREPARATION OF N OCTAHYDROPENTA (6) PYRROLE CARBOXYLATES HOECHST AKTIENGESELLSCHAFT (DE) 1991-11-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100286404-A1 PHARMACEUTICAL INTERMEDIATES IN THE SYNTHESIS OF ACE-INHIBITORS AND THE USE THEREOF ACE, AGTR1, REN ACE 1/4885MEN1 3814/4885KMT2A 4114/4885
US-20150174146-A1 ANGIOTENSIN CONVERTING ENZYME INHIBITORS FOR TREATING OPTIC NEUROPATHY OR CONGENITAL OPTIC ATROPHY ACE, ACE2, AGT ACE 1/4885MEN1 3080/4885KMT2A 3900/4885
US-20110046090-A1 MODULATION OF NEUROGENESIS WITH GABA AGENTS AND GABA ANALOGS GAP43, GABRB1, GABRB3 ACE 4514/4885MEN1 3647/4885KMT2A 2044/4885
US-20110092464-A1 NEUROGENESIS BY MODULATING ANGIOTENSIN DCX, NGF, BDNF ACE 10/4885MEN1 2541/4885KMT2A 2068/4885
US-20110269717-A1 NEUROGENESIS BY MODULATING ANGIOTENSIN NGF, DCX, BDNF ACE 6/4885MEN1 1910/4885KMT2A 1893/4885
US-20090214652-A1 SOFT TISSUE IMPLANTS AND ANTI-SCARRING AGENTS MMP1, COL2A1, FN1 ACE 2888/4885MEN1 3324/4885KMT2A 3542/4885
US-20220117936-A1 BIOSENSING PLATFORM FOR DETECTING VIRAL INFECTIONS AND METHODS FOR SCREENING A MODULATOR OF VIRAL INFECTIONS AND PROTECTING THEREFROM ACE2, ACE, TMPRSS2 ACE 2/4885MEN1 4392/4885KMT2A 4152/4885
US-20080167291-A1 NEUROGENESIS BY MODULATING ANGIOTENSIN DCX, NGF, BDNF ACE 10/4885MEN1 2535/4885KMT2A 2105/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.