Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21582183 | 0.86 | ALDH1A1 (0.44) | MAOAMAOBHTR2AKCNH2SMN1; SMN2 | |
| SCHEMBL2408105 | 0.82 | SIGMAR1 (0.48) | SIGMAR1MAOAMAOBHTR2AKCNH2 | |
| SCHEMBL28780966 | 0.81 | PPARG (0.46) | MAOBKCNH2IDO1HDAC3HDAC4 | |
| SCHEMBL9244748 | 0.78 | SIGMAR1 (0.45) | SIGMAR1MAOAMAOBHTR2AKCNH2 | |
| SCHEMBL5610357 | 0.78 | MIF (0.46) | SIGMAR1MAOAMAOBHTR2AKCNH2 | |
| SCHEMBL920968 | 0.78 | SIGMAR1 (0.47) | SIGMAR1MAOA | |
| SCHEMBL1337921 | 0.78 | HTR2A (0.48) | SIGMAR1MAOAMAOBHTR2AGRIK1 | |
| SCHEMBL5609991 | 0.78 | HDAC3 (0.47) | SIGMAR1MAOAMAOBHTR2AKCNH2 | |
| SCHEMBL6683676 | 0.78 | SIGMAR1 (0.47) | SIGMAR1MAOA | |
| SCHEMBL5502870 | 0.77 | KCNH2 (0.50) | SIGMAR1MAOAMAOBHTR2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040133938-A1 | Use of lipoic acid in plant culture media | MONSANTO TECHNOLOGY LLC | 2004-07-08 | — | — | US | disclosed |
| US-6387945-B2 | REACTING AN AMINE AND A CARBOXY-1,2-DITHIOLANE DERIVATIVE TO PRODUCE COMPOUNDS SUCH AS N,N-DIMETHYL-N-2-AMIDOETHYL LIPOATE USED TO TREAT CONDITIONS INVOLVING REACTIVE OXYGEN SPECIES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2002-05-14 | — | — | US | disclosed |
| US-20010039292-A1 | Lipoic acid analogs | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATION | 2001-11-08 | — | — | US | disclosed |
| US-6235772-B1 | OXIDATION RESISTANCE; ATHEROSCLEROSIS; AUTOIMMUNE DISEASES; BRAIN DISORDERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2001-05-22 | — | — | US | disclosed |
| EP-1061914-A1 | LIPOIC ACID ANALOGS | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2000-12-27 | — | — | EP | disclosed |
| US-6090842-A | REDUCES CONCENTRATION OF OXYGEN IN CELLS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2000-07-18 | — | — | US | disclosed |
| WO-1999045922-A1 | LIPOIC ACID ANALOGS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-09-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010039292-A1 | Lipoic acid analogs | ALOX5, ALOX15, ACSL5 | SIGMAR1 419/4885MAOA 1088/4885MAOB 841/4885 |
| US-20040133938-A1 | Use of lipoic acid in plant culture media | TTPA, TST, LRAT | SIGMAR1 4654/4885MAOA 2374/4885MAOB 2401/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.