SCHEMBL685545

SCHEMBL685545

Cc1cc(Cl)cc(C(=O)NC(C)C)c1NC(=O)c1cc(Cn2nnc(C(F)(F)F)n2)nn1-c1ncccc1Cl

nearest known ligand 0.54

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 4/20 0.33
SLC16A3 O15427 1/20 0.32
SLC16A1 P53985 1/20 0.32
MCTS1 Q9ULC4 1/20 0.32
ALDH1A1 P00352 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
CAPN1 P07384 1/20 0.31
NTRK1 P04629 1/20 0.30
MALT1 Q9UDY8 2/20 0.30
WDR5 P61964 2/20 0.30
CSF1R P07333 1/20 0.30
OPRL1 P41146 1/20 0.30
EIF2S1 P05198 1/20 0.30
EIF2AK3 Q9NZJ5 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13085020 0.94 DHODH (0.33) DHODHSLC16A3SLC16A1MCTS1ALDH1A1
SCHEMBL10075294 0.94 DHODH (0.32) DHODHSLC16A3SLC16A1MCTS1ALDH1A1
SCHEMBL13085352 0.94 DHODH (0.32) DHODHALDH1A1SMN1; SMN2NTRK1
SCHEMBL10076550 0.94 DHODH (0.33) DHODHSLC16A3SLC16A1MCTS1ALDH1A1
SCHEMBL13085066 0.94 DHODH (0.34) DHODHSLC16A3SLC16A1MCTS1ALDH1A1
SCHEMBL13084965 0.94 ALDH1A1 (0.32) DHODHALDH1A1SMN1; SMN2
SCHEMBL13085110 0.94 P2RX7 (0.33) NTRK1MALT1CSF1R
SCHEMBL11928319 0.94 DHODH (0.33) DHODHSLC16A3SLC16A1MCTS1ALDH1A1
SCHEMBL16405128 0.94 DHODH (0.33) DHODHSLC16A3SLC16A1MCTS1ALDH1A1
SCHEMBL11928141 0.93 DHODH (0.31) DHODHSLC16A3SLC16A1MCTS1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190233345-A1 AGRICULTURAL SYSTEMS, COMPOSITIONS AND METHODS FOR INCREASING CROP YIELD E. I. DU PONT DE NEMOURS AND COMPANY (US) 2019-08-01 US disclosed
US-9968086-B2 Active ingredient combinations having insecticidal and acaricidal properties BAYER INTELLECTUAL PROPERTY GMBH (DE) 2018-05-15 US disclosed
US-9968086-B2 Active ingredient combinations having insecticidal and acaricidal properties BAYER INTELLECTUAL PROPERTY GMBH (DE) 2018-05-15 US disclosed
US-9854802-B2 Use of an anthranilic diamide derivatives with heteroaromatic and heterocyclic substituents in combination with a biological control agent BAYER INTELLECTUAL PROPERTY GMBH (DE) 2018-01-02 US disclosed
US-20170362137-A1 ZEOLITE BASED AGRICULTURAL COMPOSITION E I DU PONT DE NEMOURS AND COMPANY 2017-12-21 US disclosed
US-20170362137-A1 ZEOLITE BASED AGRICULTURAL COMPOSITION E I DU PONT DE NEMOURS AND COMPANY 2017-12-21 US disclosed
WO-2017165482-A1 AGRICULTURAL SYSTEMS, COMPOSITIONS AND METHODS FOR INCREASING CROP YIELD PIONEER HI-BRED INTERNATIONAL, INC. (US) 2017-09-28 WO disclosed
US-20170265459-A1 PROPAGULE COATINGS DU PONT (US) 2017-09-21 US disclosed
US-20170265470-A1 Anthranilamides in combination with fungicides BAYER INTELLECTUAL PROPERTY GMBH (DE) 2017-09-21 US disclosed
US-20170265459-A1 PROPAGULE COATINGS DU PONT (US) 2017-09-21 US disclosed
US-8658570-B2 Use of anthranilamide derivatives for controlling insects and spider mites by drenching, soil mixing, furrow treatment, drip application, soil, stem or flower injection, in hydroponic systems, by planting hole treatment or dip application, floating or seedbox application or by treating seed, and also for enhancing the stress tolerance of plants to abiotic stress BAYER CROPSCIENCE AG (DE) 2014-02-25 US disclosed
EP-2606732-A1 Use of an anthranilic diamide derivatives with heteroaromatic and heterocyclic substituents in combination with a biological control agent Bayer CropScience AG (DE) 2013-06-26 EP disclosed
EP-2484676-A2 Tetrazol-substituted anthranilic acid amides as pesticides Bayer CropScience AG (DE) 2012-08-08 EP disclosed
US-20120022112-A1 USE OF ANTHRANILAMIDE DERIVATIVES FOR CONTROLLING INSECTS AND SPIDER MITES BY DRENCHING, SOIL MIXING, FURROW TREATMENT, DRIP APPLICATION, SOIL, STEM OR FLOWER INJECTION, IN HYDROPONIC SYSTEMS, BY PLANTING HOLE TREATMENT OR DIP APPLICATION, FLOATING OR SEEDBOX APPLICATION OR BY TREATING SEED, AND ALSO FOR ENHANCING THE STRESS TOLERANCE OF PLANTS TO ABIOTIC STRESS BAYER CROPSCIENCE AG (DE) 2012-01-26 US disclosed
US-20120022112-A1 USE OF ANTHRANILAMIDE DERIVATIVES FOR CONTROLLING INSECTS AND SPIDER MITES BY DRENCHING, SOIL MIXING, FURROW TREATMENT, DRIP APPLICATION, SOIL, STEM OR FLOWER INJECTION, IN HYDROPONIC SYSTEMS, BY PLANTING HOLE TREATMENT OR DIP APPLICATION, FLOATING OR SEEDBOX APPLICATION OR BY TREATING SEED, AND ALSO FOR ENHANCING THE STRESS TOLERANCE OF PLANTS TO ABIOTIC STRESS BAYER CROPSCIENCE AG (DE) 2012-01-26 US disclosed
US-20120010073-A1 Anthranilamides in combination with fungicides BAYER CROPSCIENCE AG (DE) 2012-01-12 US disclosed
US-20120010073-A1 Anthranilamides in combination with fungicides BAYER CROPSCIENCE AG (DE) 2012-01-12 US disclosed
US-20110311503-A1 Active ingredient combinations having insecticidal and acaricidal properties BAYER CROPSCIENCE AG (DE) 2011-12-22 US disclosed
US-20110311503-A1 Active ingredient combinations having insecticidal and acaricidal properties BAYER CROPSCIENCE AG (DE) 2011-12-22 US disclosed
WO-2010069502-A2 TETRAZOLE SUBSTITUTED ANTHRANILIC ACID AMIDES AS PESTICIDES BAYER CROPSCIENCE AG (DE) 2010-06-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170265459-A1 PROPAGULE COATINGS GUSB, CD44, IPO5 DHODH 2000/4885SLC16A3 720/4885SLC16A1 1029/4885
US-20120010073-A1 Anthranilamides in combination with fungicides AADAC, ANTXR2, CYP51A1 DHODH 815/4885SLC16A3 4378/4885SLC16A1 4624/4885
US-20190233345-A1 AGRICULTURAL SYSTEMS, COMPOSITIONS AND METHODS FOR INCREASING CROP YIELD PPA1, NANS, GYS2 DHODH 841/4885SLC16A3 1394/4885SLC16A1 2007/4885
US-20120022112-A1 USE OF ANTHRANILAMIDE DERIVATIVES FOR CONTROLLING INSECTS AND SPIDER MITES BY DRENCHING, SOIL MIXING, FURROW TREATMENT, DRIP APPLICATION, SOIL, STEM OR FLOWER INJECTION, IN HYDROPONIC SYSTEMS, BY PLANTING HOLE TREATMENT OR DIP APPLICATION, FLOATING OR SEEDBOX APPLICATION OR BY TREATING SEED, AND ALSO FOR ENHANCING THE STRESS TOLERANCE OF PLANTS TO ABIOTIC STRESS CDY1; CDY1B, DHX9, DHX29 DHODH 265/4885SLC16A3 4493/4885SLC16A1 4702/4885
US-20170265470-A1 Anthranilamides in combination with fungicides AADAC, ANTXR2, CYP51A1 DHODH 815/4885SLC16A3 4378/4885SLC16A1 4624/4885
US-20110311503-A1 Active ingredient combinations having insecticidal and acaricidal properties ACHE, ACAT1, ACAT2 DHODH 1758/4885SLC16A3 4417/4885SLC16A1 4430/4885
US-20170362137-A1 ZEOLITE BASED AGRICULTURAL COMPOSITION GHDC, SLC39A14, SLC39A11 DHODH 4154/4885SLC16A3 215/4885SLC16A1 392/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.