Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 3/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6943637 | 0.85 | P2RX7 (0.48) | P2RX7HSD11B1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL6942683 | 0.81 | ALDH1A1 (0.40) | P2RX7KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL6941696 | 0.76 | P2RX7 (0.40) | P2RX7KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL6941692 | 0.74 | STS (0.34) | P2RX7HSD11B1RAB9ALMNASMN1; SMN2 | |
| SCHEMBL15531515 | 0.67 | TRPA1 (0.41) | HSD11B1MAPTATMNPSR1EPHX2 | |
| SCHEMBL6680351 | 0.66 | EPHX2 (0.41) | P2RX7HSD11B1ALDH1A1MAPTNPSR1 | |
| SCHEMBL28144676 | 0.65 | ALDH1A1 (0.39) | HSD11B1ALDH1A1TSHRHTTHSD17B10 | |
| SCHEMBL7813283 | 0.65 | HSD11B1 (0.44) | P2RX7HSD11B1KDM4EALDH1A1HPGD | |
| SCHEMBL11858437 | 0.64 | ALDH1A1 (0.38) | HSD11B1ALDH1A1TSHRHTTRAB9A | |
| SCHEMBL30978073 | 0.63 | MAPT (0.37) | P2RX7HSD11B1KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036058-B1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2003-03-12 | — | — | EP | claimed |