Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.51 |
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7069907 | 0.92 | VCAM1 (0.52) | SMN1; SMN2KMT2AMEN1L3MBTL1LMNA | |
| SCHEMBL7074664 | 0.88 | THRB (0.53) | SMN1; SMN2KMT2AMEN1THRBGAA | |
| SCHEMBL7073993 | 0.87 | ALDH1A1 (0.60) | SMN1; SMN2KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL7069359 | 0.84 | THRB (0.48) | SMN1; SMN2KMT2AMEN1THRBGAA | |
| SCHEMBL8073643 | 0.84 | ALDH1A1 (0.56) | SMN1; SMN2KMT2AALDH1A1LMNA | |
| SCHEMBL7074222 | 0.83 | LMNA (0.62) | SMN1; SMN2KMT2AMEN1L3MBTL1THRB | |
| SCHEMBL7076713 | 0.83 | RAB9A (0.54) | SMN1; SMN2KMT2AMEN1THRBLMNA | |
| SCHEMBL7075993 | 0.83 | ATM (0.66) | SMN1; SMN2KMT2AMEN1L3MBTL1GAA | |
| SCHEMBL7074172 | 0.82 | SMN1; SMN2 (0.56) | SMN1; SMN2KMT2AMEN1THRBGAA | |
| SCHEMBL7076646 | 0.82 | ALDH1A1 (0.50) | KMT2AMEN1L3MBTL1THRBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025086-B1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 2003-06-25 | — | — | EP | disclosed |
| US-6492368-B1 | Benzamidine derivatives as factor XA inhibitors | MERCK PATENT GMBH (DE) | 2002-12-10 | — | — | US | disclosed |