Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.30 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7211824 | 1.00 | ACACB (0.36) | ACACBTAAR1ALDH1A1GAACYP1A2 | |
| SCHEMBL3685622 | 0.84 | TSHR (0.48) | ACACBALDH1A1MAPK1CYP2C19TSHR | |
| SCHEMBL8961250 | 0.82 | ACACB (0.38) | ACACBTAAR1ALDH1A1GAACYP1A2 | |
| SCHEMBL8961255 | 0.82 | ACACB (0.38) | ACACBTAAR1ALDH1A1GAACYP1A2 | |
| Potassium Ion SCHEMBL9616732 | 0.81 | TSHR (0.48) | ACACBALDH1A1MAPK1CYP2C19TSHR | |
| SCHEMBL20450459 | 0.74 | TAS1R3 (0.47) | ACACBTAAR1ALDH1A1GAATSHR | |
| SCHEMBL20586386 | 0.71 | CNR2 (0.45) | ACACBTAAR1ALDH1A1GAACYP1A2 | |
| SCHEMBL27602907 | 0.70 | TGFBR1 (0.44) | — | |
| SCHEMBL27651780 | 0.69 | ACACB (0.39) | ACACBTAAR1ALDH1A1GAACYP1A2 | |
| SCHEMBL9578217 | 0.69 | POLB (0.43) | L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0558612-B1 | POLYMER BLENDS FOR AQUEOUS DISPERSIONS HAVING IMPROVED FREEZE-THAW STABILITY | EASTMAN CHEM CO (US) | 1996-01-10 | — | — | EP | claimed |
| US-5268412-A | Sulfonate group containing poly(amide)esters | EASTMAN KODAK COMPANY (US) | 1993-12-07 | — | — | US | claimed |
| EP-0558612-A1 | POLYMER BLENDS FOR AQUEOUS DISPERSIONS HAVING IMPROVED FREEZE-THAW STABILITY. | EASTMAN KODAK CO (US) | 1993-09-08 | — | — | EP | claimed |
| WO-1992009657-A1 | POLYMER BLENDS FOR AQUEOUS DISPERSIONS HAVING IMPROVED FREEZE-THAW STABILITY | EASTMAN KODAK COMPANY (US) | 1992-06-11 | — | — | WO | claimed |
| US-6548571-B1 | Mixing ink, colorant and latex generated by addition poymerization of A-olefin and sodium- or potassium vinylsulfonate | XEROX CORPORATION | 2003-04-15 | — | — | US | disclosed |
| EP-0558612-B1 | POLYMER BLENDS FOR AQUEOUS DISPERSIONS HAVING IMPROVED FREEZE-THAW STABILITY | EASTMAN CHEM CO (US) | 1996-01-10 | — | — | EP | disclosed |
| US-5268412-A | Sulfonate group containing poly(amide)esters | EASTMAN KODAK COMPANY (US) | 1993-12-07 | — | — | US | disclosed |