Orilotimod

Orilotimod

SCHEMBL733964

N[C@H](CCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O)C(=O)O

nearest known ligand 0.65

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.65
MEN1 O00255 1/20 0.65
LMNA P02545 1/20 0.65
MPO P05164 1/20 0.65
MAPT P10636 1/20 0.65
TSHR P16473 1/20 0.65
BLM P54132 1/20 0.65
PMP22 Q01453 1/20 0.65
KMT2A Q03164 1/20 0.65
HIF1A Q16665 1/20 0.65
ERAP2 Q6P179 2/20 0.62
ALOX15 P16050 1/20 0.61
ACE P12821 4/20 0.61
ITGB2 P05107 4/20 0.60
ICAM1 P05362 4/20 0.60
ITGAL P20701 4/20 0.60
PPARG P37231 1/20 0.59
P2RY14 Q15391 1/20 0.59
TP53 P04637 1/20 0.59
POLB P06746 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Golotimod SCHEMBL14790029 1.00 KDM4E (0.65) KDM4EMEN1LMNAMPOMAPT
Golotimod SCHEMBL12966340 1.00 KDM4E (0.65) KDM4EMEN1LMNAMPOMAPT
Golotimod SCHEMBL727944 1.00 KDM4E (0.65) KDM4EMEN1LMNAMPOMAPT
Golotimod SCHEMBL1768729 1.00 KDM4E (0.65) KDM4EMEN1LMNAMPOMAPT
Golotimod SCHEMBL726291 1.00 KDM4E (0.65) KDM4EMEN1LMNAMPOMAPT
Golotimod SCHEMBL12818886 1.00 KDM4E (0.65) KDM4EMEN1LMNAMPOMAPT
Golotimod SCHEMBL29622906 1.00 KDM4E (0.65) KDM4EMEN1LMNAMPOMAPT
Golotimod SCHEMBL726938 1.00 KDM4E (0.65) KDM4EMEN1LMNAMPOMAPT
Orilotimod SCHEMBL29379690 1.00 KDM4E (0.65) KDM4EMEN1LMNAMPOMAPT
SCHEMBL645413 0.93 ERAP2 (0.60) KDM4EMEN1LMNAMPOMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150225341-A1 PHARMACEUTICALLY ACCEPTABLE SALTS OF THYMODEPRESSIN AND PROCESSES FOR THEIR MANUFACTURE APOTEX TECHNOLOGIES INC. 2015-08-13 US disclosed
US-20150225341-A1 PHARMACEUTICALLY ACCEPTABLE SALTS OF THYMODEPRESSIN AND PROCESSES FOR THEIR MANUFACTURE APOTEX TECHNOLOGIES INC. 2015-08-13 US disclosed
US-20150011484-A1 PRODRUGS OF D-GAMMA-GLUTAMYL-D-TRYPTOPHAN AND D-GAMMA-GLUTAMYL-L-TRYPTOPHAN APTOEX TECHNOLOGIES, INC. (CA) 2015-01-08 US disclosed
US-20150011484-A1 PRODRUGS OF D-GAMMA-GLUTAMYL-D-TRYPTOPHAN AND D-GAMMA-GLUTAMYL-L-TRYPTOPHAN APTOEX TECHNOLOGIES, INC. (CA) 2015-01-08 US disclosed
US-20140343050-A1 PRODRUGS OF D-ISOGLUTAMYL-[D/L]-TRYPTOPHAN APTOEX TECHNOLOGIES, INC. (CA) 2014-11-20 US disclosed
US-8735602-B2 Pharmaceutically acceptable salts of thymodepressin and processes for their manufacture APOTEX TECHNOLOGIES INC. (CA) 2014-05-27 US disclosed
US-8735602-B2 Pharmaceutically acceptable salts of thymodepressin and processes for their manufacture APOTEX TECHNOLOGIES INC. (CA) 2014-05-27 US disclosed
US-8664262-B2 Crystalline forms of the mono-sodium salt of D-isoglutamyl-D-tryptophan APOTEX TECHNOLOGIES INC. (CA) 2014-03-04 US disclosed
US-8664262-B2 Crystalline forms of the mono-sodium salt of D-isoglutamyl-D-tryptophan APOTEX TECHNOLOGIES INC. (CA) 2014-03-04 US disclosed
EP-2691370-A1 PRODRUGS OF D-GAMMA-GLUTAMYL-D-TRYPTOPHAN AND D-GAMMA- GLUTAMYL-L-TRYPTOPHAN Apotex Technologies Inc. (CA) 2014-02-05 EP disclosed
US-20100056803-A1 Pharmaceutically Acceptable Salts of Thymodepressin and Processes for their Manufacture APOTEX TECHNOLOGIES INC. (CA) 2010-03-04 US disclosed
US-20100056803-A1 Pharmaceutically Acceptable Salts of Thymodepressin and Processes for their Manufacture APOTEX TECHNOLOGIES INC. (CA) 2010-03-04 US disclosed
US-20100029742-A1 CRYSTALLINE FORMS OF THE MONO-SODIUM SALT OF D-ISOGLUTAMYL-D-TRYPTOPHAN APOTEX TECHNOLOGIES INC. (CA) 2010-02-04 US disclosed
US-20100029742-A1 CRYSTALLINE FORMS OF THE MONO-SODIUM SALT OF D-ISOGLUTAMYL-D-TRYPTOPHAN APOTEX TECHNOLOGIES INC. (CA) 2010-02-04 US disclosed
US-20100016243-A1 CRYSTALLINE D-ISOGLUTAMYL-D-TRYPTOPHAN AND THE MONO AMMONIUM SALT OF D-ISOGLUTAMYL-D-TRYPTOPHAN APOTEX TECHNOLOGIES INC. (CA) 2010-01-21 US disclosed
US-20100016243-A1 CRYSTALLINE D-ISOGLUTAMYL-D-TRYPTOPHAN AND THE MONO AMMONIUM SALT OF D-ISOGLUTAMYL-D-TRYPTOPHAN APOTEX TECHNOLOGIES INC. (CA) 2010-01-21 US disclosed
WO-2008098355-A1 CRYSTALLINE FORMS OF THE MONO-SODIUM SALT OF D-ISOGLUTAMYL-D-TRYPTOPHAN APOTEX TECHNOLOGIES INC. (CA) 2008-08-21 WO disclosed
WO-2008074128-A1 PHARMACEUTICALLY ACCEPTABLE SALTS OF THYMODEPRESSIN AND PROCESSES FOR THEIR MANUFACTURE APOTEX TECHNOLOGIES INC. (CA) 2008-06-26 WO disclosed
WO-2008064465-A1 CRYSTALLINE D-ISOGLUTAMYL-D-TRYPTOPHAN AND THE MONO AMMONIUM SALT OF D-ISOGLUTAMYL- D-TRYPTOPHAN APOTEX TECHNOLOGIES INC. (CA) 2008-06-05 WO disclosed
US-5916878-A DIPEPTIDE OF EITHER GAMMA-GLUTAMYL-L-TRYPTOPHAN OR BETA-ASPARTYL-L-TRYPTOPHAN; ADMINISTERING TO THE PATIENTS TO REDUCE THE RISKS INFECTIONS FROM MICROORGANISM Wei, Edward T. (US) 1999-06-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100029742-A1 CRYSTALLINE FORMS OF THE MONO-SODIUM SALT OF D-ISOGLUTAMYL-D-TRYPTOPHAN TPH1, AADAT, KYNU KDM4E 2612/4885MEN1 907/4885LMNA 2140/4885
US-20140343050-A1 PRODRUGS OF D-ISOGLUTAMYL-[D/L]-TRYPTOPHAN TPH1, TYMS, TDO2 KDM4E 3178/4885MEN1 2526/4885LMNA 1457/4885
US-20100056803-A1 Pharmaceutically Acceptable Salts of Thymodepressin and Processes for their Manufacture TPH1, CACNA1G, CACNA1S KDM4E 2406/4885MEN1 923/4885LMNA 3219/4885
US-20100016243-A1 CRYSTALLINE D-ISOGLUTAMYL-D-TRYPTOPHAN AND THE MONO AMMONIUM SALT OF D-ISOGLUTAMYL-D-TRYPTOPHAN DDC, AADAT, GLUL KDM4E 1255/4885MEN1 2768/4885LMNA 1841/4885
US-20150011484-A1 PRODRUGS OF D-GAMMA-GLUTAMYL-D-TRYPTOPHAN AND D-GAMMA-GLUTAMYL-L-TRYPTOPHAN TPH1, GCG, GLUL KDM4E 3537/4885MEN1 1065/4885LMNA 625/4885
US-20150225341-A1 PHARMACEUTICALLY ACCEPTABLE SALTS OF THYMODEPRESSIN AND PROCESSES FOR THEIR MANUFACTURE TMSB10, TMSB4X, TSLP KDM4E 1489/4885MEN1 1217/4885LMNA 3098/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.