SCHEMBL742940

SCHEMBL742940

NS(=O)(=O)c1cccc(Cl)c1Cl

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGES2 Q9H7Z7 11/20 0.64
LMNA P02545 3/20 0.53
KDM4E B2RXH2 1/20 0.53
MEN1 O00255 1/20 0.53
ALDH1A1 P00352 1/20 0.53
KMT2A Q03164 1/20 0.53
TSHR P16473 1/20 0.52
CA1 P00915 4/20 0.50
CA2 P00918 4/20 0.50
CA9 Q16790 3/20 0.50
CA4 P22748 3/20 0.50
CA6 P23280 3/20 0.50
CA12 O43570 2/20 0.50
CYP2C9 P11712 2/20 0.50
CA5A P35218 2/20 0.50
CA7 P43166 2/20 0.50
CA14 Q9ULX7 2/20 0.50
CA5B Q9Y2D0 2/20 0.50
CA13 Q8N1Q1 1/20 0.50
MCOLN3 Q8TDD5 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29578190 1.00 PTGES2 (0.64) PTGES2LMNAKDM4EMEN1ALDH1A1
SCHEMBL10593744 0.88 CA2 (0.52) PTGES2LMNAKDM4EMEN1ALDH1A1
SCHEMBL11647231 0.82 CA1 (0.52) PTGES2LMNAKDM4EMEN1ALDH1A1
SCHEMBL121865 0.81 CA2 (0.56) PTGES2LMNAALDH1A1TSHRCA1
SCHEMBL29356372 0.81 CA2 (0.56) PTGES2LMNAALDH1A1TSHRCA1
SCHEMBL1248188 0.81 AKR1B1 (0.56) PTGES2LMNAMEN1ALDH1A1KMT2A
SCHEMBL25301662 0.80 CA2 (0.45) PTGES2LMNAKDM4EMEN1ALDH1A1
SCHEMBL3531209 0.80 CA2 (0.61) PTGES2LMNAKDM4EMEN1ALDH1A1
SCHEMBL28335651 0.80 CA2 (0.61) PTGES2LMNAKDM4EMEN1ALDH1A1
SCHEMBL3775622 0.79 PTGES2 (1.00) PTGES2CA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 150 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113966397-A Human carbonic anhydrase 2 compositions and methods for tunable modulation 黑曜石疗法公司 2022-01-21 CN claimed
WO-2019048988-A1 NOVEL FUNGIDAL HETEROCYCLIC COMPOUNDS PI INDUSTRIES LTD. (IN) 2019-03-14 WO claimed
EP-3186333-A2 ANTIMICROBIAL COMPOSITIONS AND METHODS WITH NOVEL POLYMERIC BINDING SYSTEM Cao, Zhengbing (US) 2017-07-05 EP claimed
WO-2016033340-A2 ANTIMICROBIAL COMPOSITIONS AND METHODS WITH NOVEL POLYMERIC BINDING SYSTEM CAO ZHENGBING (US) 2016-03-03 WO claimed
WO-2007035154-A1 NOVEL N-PYRAZINIL-PHENYLSULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS FOR USE IN THE TREATMENT OF ASTHMA ASTRAZENECA AB (SE) 2007-03-29 WO claimed
US-20010031781-A1 Heteroaryl amidines, methylamidines and guanidines and use thereof as protease inhibitors ILLIG CARL R (US) 2001-10-18 US claimed
EP-0315204-A2 Bleaching composition LION CORPORATION (JP) 1989-05-10 EP claimed
JP-61254631-A None JP disclosed
JP-61254630-A None JP disclosed
US-20260103758-A1 METHODS AND BIOMARKERS FOR TREATING BREAST CANCER KING ABDULAZIZ UNIVERSITY (SA) 2026-04-16 US disclosed
EP-3364976-B1 PIPERAZINYL NORBENZOMORPHAN COMPOUNDS AND METHODS FOR USING THE SAME UNIV TEXAS (US) 2026-03-18 EP disclosed
US-12527763-B2 Pyrrole amide compound and use thereof SUNSHINE LAKE PHARMA CO., LTD. (CN) 2026-01-20 US disclosed
US-20250320184-A1 SARM1 MODULATORS, PREPARATIONS, AND USES THEREOF SIRONAX LTD (KY) 2025-10-16 US disclosed
WO-1995022785-A1 PHOTOTHERMOGRAPHIC ELEMENT WITH CORE-SHELL-TYPE SILVER HALIDE GRAINS MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1995-08-24 WO disclosed
EP-0328291-A1 Halogenated polybutadiene series elastomers, method of producing the same, and rubber compositions for tires containing the elastomer Bridgestone Corporation (JP) 1989-08-16 EP disclosed
US-4645527-A PLANT SAFENING AGENT E. I. DU PONT DE NEMOURS AND COMPANY (US) 1987-02-24 US disclosed
JP-S61254631-A BONDING OF PHOTO-SENSITIVE FLEXOGRAPHIC PRINTING PLATE AND RUBBER BACKING MATERIAL NIPPON ZEON CO LTD 1986-11-12 JP disclosed
JP-S61254630-A METHOD FOR BONDING RUBBERY SHEET AND POLYESTER SHEET NIPPON ZEON CO LTD 1986-11-12 JP disclosed
EP-0060120-B1 PROCESS FOR PREPARING 4-HALOAZETIDIN-2-ONES ELI LILLY AND COMPANY (US) 1984-12-19 EP disclosed
EP-0033984-B1 NEW SULPHONYL COMPOUNDS, METHOD OF PREPARING THE NEW COMPOUNDS, AS WELL AS APHICIDAL COMPOSITIONS ON THE BASIS OF THE NEW COMPOUNDS DUPHAR INTERNATIONAL RESEARCH B.V (NL) 1984-06-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250320184-A1 SARM1 MODULATORS, PREPARATIONS, AND USES THEREOF SARM1, SMN1; SMN2, ADRM1 PTGES2 3788/4885LMNA 907/4885KDM4E 3435/4885
US-20260103758-A1 METHODS AND BIOMARKERS FOR TREATING BREAST CANCER THRAP3, ACTR2, ACTR3 PTGES2 3755/4885LMNA 4298/4885KDM4E 4488/4885
US-12527763-B2 Pyrrole amide compound and use thereof NR3C2, AVPR2, MC2R PTGES2 354/4885LMNA 3885/4885KDM4E 1437/4885
US-20010031781-A1 Heteroaryl amidines, methylamidines and guanidines and use thereof as protease inhibitors SERPINE1, PRSS3, PRSS2 PTGES2 3057/4885LMNA 850/4885KDM4E 3095/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.