SCHEMBL7440735

SCHEMBL7440735

O=C1CN(Cc2cccc3ccccc23)C(=O)N1C(S)CCc1ccccc1

nearest known ligand 0.42

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.42
KMT2A Q03164 2/20 0.41
CLPP Q16740 5/20 0.41
MEN1 O00255 1/20 0.40
XIAP P98170 1/20 0.39
ENPP2 Q13822 1/20 0.38
HDAC1 Q13547 1/20 0.37
CMA1 P23946 1/20 0.37
CTNNB1 P35222 2/20 0.36
TCF7 P36402 2/20 0.36
METAP2 P50579 1/20 0.36
BCL9 O00512 1/20 0.36
TCF4 P15884 1/20 0.36
CREBBP Q92793 1/20 0.36
ALDH1A1 P00352 1/20 0.36
GAA P10253 1/20 0.36
SIGMAR1 Q99720 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7432645 0.85 ENPP2 (0.47) L3MBTL1KMT2AMEN1ENPP2ALDH1A1
SCHEMBL7440724 0.81 HRH4 (0.43) L3MBTL1KMT2ACLPPMEN1ENPP2
SCHEMBL7428792 0.77 CYP2D6 (0.45) KMT2AENPP2
SCHEMBL7445702 0.76 ACHE (0.40) L3MBTL1KMT2AMEN1ENPP2ALDH1A1
SCHEMBL7426522 0.75 MAPT (0.43) L3MBTL1KMT2AMEN1ENPP2HDAC1
SCHEMBL7435811 0.74 ACHE (0.41) L3MBTL1KMT2AMEN1ENPP2GAA
SCHEMBL7436003 0.74 HDAC6 (0.42) L3MBTL1KMT2AMEN1ENPP2HDAC1
SCHEMBL7426794 0.71 POLB (0.37) L3MBTL1KMT2AMEN1ALDH1A1GAA
SCHEMBL7428456 0.70 PLA2G10 (0.45) ENPP2ALDH1A1
SCHEMBL7425893 0.69 KMT2A (0.44) KMT2AMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0640594-A1 Hydantoin derivative as metalloprotease inhibitor FUJIREBIO INC. (JP) 1995-03-01 EP disclosed