Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.41 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7482004 | 0.90 | ALDH1A1 (0.46) | HTTALDH1A1CYP2C19CYP2C9LMNA | |
| SCHEMBL7474643 | 0.83 | ALDH1A1 (0.45) | ALDH1A1CYP1A2CYP3A4CYP2C19RAB9A | |
| SCHEMBL7478795 | 0.83 | LMNA (0.45) | ALDH1A1RAB9ALMNAKMT2AMEN1 | |
| SCHEMBL7477845 | 0.83 | MMP9 (0.42) | HTTALDH1A1CYP3A4CYP2C19CYP2C9 | |
| SCHEMBL7475641 | 0.83 | PTGS2 (0.44) | HTTALDH1A1CYP2D6CYP2C9RAB9A | |
| SCHEMBL7475491 | 0.80 | PLK1 (0.45) | HTTALDH1A1RAB9AGAA | |
| SCHEMBL7484780 | 0.80 | MMP9 (0.46) | RAB9AKMT2AMEN1EPHX2 | |
| SCHEMBL7478759 | 0.80 | MMP2 (0.43) | ALDH1A1RAB9ALMNAKMT2AMEN1 | |
| SCHEMBL7482164 | 0.80 | MMP2 (0.49) | HTTALDH1A1RAB9AKMT2AKDM4E | |
| SCHEMBL7474409 | 0.79 | MAOA (0.54) | KMT2AMEN1GAACA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6472396-B1 | Barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-29 | — | — | US | claimed |
| EP-0869947-B1 | BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-23 | — | — | EP | disclosed |