Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7479933 | 0.88 | ALDH1A1 (0.51) | MAPTCYP3A4CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL7483466 | 0.84 | SLC6A5 (0.48) | MAPTGAAKDM4EHTTNPC1 | |
| SCHEMBL7475852 | 0.76 | KMT2A (0.53) | MAPTALDH1A1KDM4ETDP1NPC1 | |
| SCHEMBL7482164 | 0.76 | MMP2 (0.49) | ALDH1A1GAAKDM4EHTTNPC1 | |
| SCHEMBL7480996 | 0.75 | RAB9A (0.56) | MAPTALDH1A1TDP1NPC1RAB9A | |
| SCHEMBL7478795 | 0.74 | LMNA (0.45) | MAPTALDH1A1GAANPC1RAB9A | |
| SCHEMBL6565869 | 0.74 | TSHR (0.68) | MAPTCYP2C19ALDH1A1GAAKDM4E | |
| SCHEMBL7483158 | 0.73 | MMP9 (0.41) | MAPTALDH1A1GAAKDM4ETDP1 | |
| SCHEMBL7472887 | 0.71 | ALDH1A1 (0.48) | MAPTALDH1A1GAAHTTTDP1 | |
| SCHEMBL11279398 | 0.70 | TSHR (0.50) | MAPTCYP3A4CYP2C9CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0869947-B1 | BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-23 | — | — | EP | disclosed |