Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL752477 | 0.95 | TP53 (0.42) | TP53CALM1NR1H2NR1H3TSHR | |
| Lithium Ion SCHEMBL751524 | 0.95 | TP53 (0.42) | TP53CALM1NR1H2NR1H3TSHR | |
| SCHEMBL816643 | 0.95 | TP53 (0.42) | TP53CALM1NR1H2NR1H3TSHR | |
| Lithium Ion SCHEMBL6861281 | 0.81 | TP53 (0.39) | TP53CALM1NR1H2NR1H3TSHR | |
| SCHEMBL16378246 | 0.76 | TP53 (0.48) | TP53CALM1NR1H2NR1H3TSHR | |
| SCHEMBL231005 | 0.76 | ESR1 (0.56) | TP53CALM1NR1H2NR1H3TSHR | |
| SCHEMBL1107767 | 0.76 | TP53 (0.48) | TP53CALM1NR1H2NR1H3TSHR | |
| SCHEMBL749370 | 0.75 | TP53 (0.42) | TP53CALM1NR1H2NR1H3TSHR | |
| SCHEMBL751758 | 0.73 | TAAR1 (0.39) | TP53CALM1TSHRALDH1A1TRPA1 | |
| SCHEMBL9224737 | 0.72 | TP53 (0.43) | TP53CALM1NR1H2NR1H3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10611775-B2 | Thiophene derivatives | TIANJIN HEMAY PHARMACEUTICAL CO., LTD. (CN) | 2020-04-07 | — | — | US | disclosed |
| US-20190322684-A1 | THIOPHENE DERIVATIVES | TIANJIN HEMAY PHARMACEUTICAL CO., LTD. (CN) | 2019-10-24 | — | — | US | disclosed |
| US-10385062-B2 | Thiophene derivatives | TIANJIN HEMAY BIO-TECH CO., LTD. (CN) | 2019-08-20 | — | — | US | disclosed |
| US-20170197982-A1 | THIOPHENE DERIVATIVES | GANZHOU HEMAY PHARMACEUTICAL CO., LTD. (CN) | 2017-07-13 | — | — | US | disclosed |
| US-9630975-B2 | Thiophene derivatives | TIANJIN HEMAY BIO-TECH CO., LTD. (CN) | 2017-04-25 | — | — | US | disclosed |
| US-8952178-B2 | Thiophene derivatives | TIANJIN HEMAY BIO-TECH CO., LTD. (CN) | 2015-02-10 | — | — | US | disclosed |
| US-20140255342-A1 | THIOPHENE DERIVATIVES | TIANJIN HEMAY BIO-TECH CO., LTD. (CN) | 2014-09-11 | — | — | US | disclosed |
| EP-2431371-B1 | THIOPHENE DERIVATIVES | TIANJIN HEMAY BIO TECH CO LTD (CN) | 2013-10-09 | — | — | EP | disclosed |
| US-20120107269-A1 | THIOPHENE DERIVATIVES | Tianjin Hemay Biotech Co., Ltd (CN) | 2012-05-03 | — | — | US | disclosed |
| US-8153545-B2 | Process for homo—or copolymerization of conjugated olefins | STYRON EUROPE GMBH (CH) | 2012-04-10 | — | — | US | disclosed |
| EP-2431371-A1 | THIOPHENE DERIVATIVES | Tianjin Hemay Bio-Tech Co., Ltd. (CN) | 2012-03-21 | — | — | EP | disclosed |
| US-20110160041-A1 | PROCESS FOR HOMO - OR COPOLYMERIZATION OF CONJUGATED OLEFINS | STYRON EUROPE GMBH | 2011-06-30 | — | — | US | disclosed |
| US-20100248947-A1 | PROCESS FOR HOMO - OR COPOLYMERIZATION OF CONJUGATED OLEFINS | DOW GLOBAL TECHNOLOGIES INC. (US) | 2010-09-30 | — | — | US | disclosed |
| US-7612009-B2 | Process for homo-or copolymerization of conjugated olefines | DOW GLOBAL TECHNOLOGIES, INC. (US) | 2009-11-03 | — | — | US | disclosed |
| US-20060142145-A1 | Process for homo-or copolymerization of conjugated olefines | TRINSEO EUROPE GMBH (CH) | 2006-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110160041-A1 | PROCESS FOR HOMO - OR COPOLYMERIZATION OF CONJUGATED OLEFINS | F12, ETFB, F2 | TP53 4774/4885CALM1 4158/4885NR1H2 1603/4885 |
| US-10385062-B2 | Thiophene derivatives | TSHR, RB1, TAS2R7 | TP53 1696/4885CALM1 2734/4885NR1H2 377/4885 |
| US-20120107269-A1 | THIOPHENE DERIVATIVES | TSHR, RB1, TAS2R7 | TP53 1696/4885CALM1 2734/4885NR1H2 377/4885 |
| US-10611775-B2 | Thiophene derivatives | TSHR, RB1, TAS2R7 | TP53 1696/4885CALM1 2734/4885NR1H2 377/4885 |
| US-20170197982-A1 | THIOPHENE DERIVATIVES | TSHR, RB1, TAS2R7 | TP53 1696/4885CALM1 2734/4885NR1H2 377/4885 |
| US-20060142145-A1 | Process for homo-or copolymerization of conjugated olefines | ETFB, F12, F2 | TP53 4739/4885CALM1 4515/4885NR1H2 2295/4885 |
| US-20140255342-A1 | THIOPHENE DERIVATIVES | TSHR, RB1, TAS2R7 | TP53 1696/4885CALM1 2734/4885NR1H2 377/4885 |
| US-20190322684-A1 | THIOPHENE DERIVATIVES | TSHR, RB1, TAS2R7 | TP53 1696/4885CALM1 2734/4885NR1H2 377/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.