Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | CFTR | P13569 | 1/20 | 0.31 |
| ▸ | GHSR | Q92847 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4767101 | 0.75 | CTSD (0.37) | SLC6A2SLC6A4SLC6A3KCNH2GHSR | |
| SCHEMBL6770905 | 0.73 | GHSR (0.38) | SLC6A2SLC6A4SLC6A3KCNH2GHSR | |
| SCHEMBL4936544 | 0.69 | GHSR (0.37) | SLC6A2SLC6A4SLC6A3GHSR | |
| SCHEMBL4766714 | 0.69 | GHSR (0.37) | SLC6A2SLC6A4SLC6A3GHSR | |
| SCHEMBL7430902 | 0.68 | ALDH1A1 (0.38) | SLC6A2SLC6A4GHSR | |
| SCHEMBL6633602 | 0.66 | SLC6A2 (0.40) | SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL6588875 | 0.65 | CTSK (0.39) | — | |
| SCHEMBL7570056 | 0.64 | OPRM1 (0.47) | SLC6A2SLC6A4 | |
| SCHEMBL7562358 | 0.64 | ACKR3 (0.45) | SLC6A2SLC6A4 | |
| SCHEMBL6587495 | 0.63 | TRPM8 (0.35) | SLC6A2SLC6A4SLC6A3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1158986-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2002-03-27 | — | — | EP | disclosed |
| EP-1158986-A1 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000038687-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-07-06 | — | — | WO | disclosed |