Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | G6PC1 | P35575 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.39 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8141068 | 1.00 | LMNA (0.48) | LMNAL3MBTL1CA2ALDH1A1TSHR | |
| SCHEMBL6888679 | 1.00 | LMNA (0.48) | LMNAL3MBTL1CA2ALDH1A1TSHR | |
| SCHEMBL20871102 | 0.78 | RAB9A (0.52) | L3MBTL1CA2ALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL3567649 | 0.78 | NPC1 (0.41) | LMNAL3MBTL1ALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL12493911 | 0.78 | CA2 (0.50) | LMNAL3MBTL1CA2ALDH1A1TSHR | |
| SCHEMBL3567647 | 0.78 | NPC1 (0.41) | LMNAL3MBTL1ALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL12493915 | 0.78 | CA2 (0.50) | LMNAL3MBTL1CA2ALDH1A1TSHR | |
| SCHEMBL6893957 | 0.78 | ALDH1A1 (0.56) | LMNAL3MBTL1ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL7571738 | 0.77 | LMNA (0.48) | LMNAL3MBTL1CA2ALDH1A1SMN1; SMN2 | |
| SCHEMBL12894229 | 0.77 | CA2 (0.48) | LMNAL3MBTL1CA2ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-60155114-A | — | — | None | — | — | JP | disclosed |
| JP-63264411-A | — | — | None | — | — | JP | disclosed |
| US-20240018161-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMA (US) | 2024-01-18 | — | — | US | disclosed |
| US-20240018161-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMA (US) | 2024-01-18 | — | — | US | disclosed |
| EP-4225447-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2023015191-A1 | COMPOSITIONS, SYSTEMS AND METHODS FOR ATOM TRANSFER RADICAL ADDITION REACTION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2023-02-09 | — | — | WO | disclosed |
| WO-2022076625-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |
| WO-2022076625-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |
| US-11034646-B2 | Method for the synthesis of unsymmetrical tertiary amines | Universite Paris-Saclay (FR) | 2021-06-15 | — | — | US | disclosed |
| US-20200255369-A1 | NEW METHOD FOR THE SYNTHESIS OF UNSYMMETRICAL TERTIARY AMINES | Universite Paris-Saclay (FR) | 2020-08-13 | — | — | US | disclosed |
| US-5532360-A | REACTING WITH AZOMETHINE COMPOUND TO FORM HETEROCYCLIC COMPOUND | NIPPON PAINT CO., LTD. (JP) | 1996-07-02 | — | — | US | disclosed |
| EP-0693474-A1 | NOVEL BENZYLAMINOETHOXYBENZENE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF | Toyo Boseki Kabushiki Kaisha (JP) | 1996-01-24 | — | — | EP | disclosed |
| EP-0671385-A1 | Method for handling (2-alkyl) acryloyl isocyanate, method for producing (2-alkyl)acryloyl isocyanate, heterocyclic compound, and method for producing heterocyclic compound | Nippon Paint Co., Ltd. (JP) | 1995-09-13 | — | — | EP | disclosed |
| JP-S63264411-A | CARCINOSTATIC AGENT | RIKAGAKU KENKYUSHO | 1988-11-01 | — | — | JP | disclosed |
| EP-0111286-B1 | NOVEL BETA-LACTAM DERIVATIVES AND PROCESS FOR PRODUCTION THEREOF | Sanraku Incorporated (JP) | 1988-03-02 | — | — | EP | disclosed |
| US-4727149-A | Preparation of nitriles of fused ring pyridine derivatives | JOHN WYETH & BROTHER LIMITED (GB) | 1988-02-23 | — | — | US | disclosed |
| US-4707552-A | Preparation of nitriles and thioamides of fused ring pyridine derivatives | JOHN WYETH & BROTHER LIMITED (GB) | 1987-11-17 | — | — | US | disclosed |
| JP-S60155114-A | CARCINOSTATIC AGENT | RIKAGAKU KENKYUSHO | 1985-08-15 | — | — | JP | disclosed |
| US-4517127-A | β-Lactam derivatives and process for production thereof | SANRAKU-OCEAN CO., LTD. (JP) | 1985-05-14 | — | — | US | disclosed |
| EP-0111286-A1 | Novel beta-lactam derivatives and process for production thereof | Sanraku Incorporated (JP) | 1984-06-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240018161-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | CFTR, SCNN1G, SCNN1B | LMNA 3702/4885L3MBTL1 3940/4885CA2 2703/4885 |
| US-20200255369-A1 | NEW METHOD FOR THE SYNTHESIS OF UNSYMMETRICAL TERTIARY AMINES | ADH1C, ADH1A, ADH5 | LMNA 944/4885L3MBTL1 4036/4885CA2 4835/4885 |
| US-11034646-B2 | Method for the synthesis of unsymmetrical tertiary amines | ADH1C, PNMT, ADH1A | LMNA 1096/4885L3MBTL1 3863/4885CA2 4822/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.