SCHEMBL7706489

SCHEMBL7706489

CC(=O)N1CC(=S)C[C@H]1C(=O)O.COc1ccc(CC(=O)Nc2cccc(CC(N)C(=O)O)c2)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NLRP3 Q96P20 2/20 0.46
USP2 O75604 1/20 0.45
SMN1; SMN2 Q16637 2/20 0.44
ACKR3 P25106 1/20 0.43
ALDH1A1 P00352 3/20 0.42
MAPT P10636 2/20 0.42
RAB9A P51151 1/20 0.42
NOS3 P29474 1/20 0.42
NOS1 P29475 1/20 0.42
NOS2 P35228 1/20 0.42
HDAC8 Q9BY41 1/20 0.41
SLC7A5 Q01650 1/20 0.41
CRHBP P24387 1/20 0.40
CRHR2 Q13324 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
AURKA O14965 1/20 0.39
RPS6KB1 P23443 1/20 0.39
LMNA P02545 2/20 0.39
KDM4E B2RXH2 1/20 0.39
HPGD P15428 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7709540 0.85 NOS3 (0.43) ACKR3MAPTNOS3NOS1NOS2
SCHEMBL7709242 0.82 NOS3 (0.47) NOS3NOS1NOS2SLC7A5
SCHEMBL7905211 0.79 ITGB1 (0.43) SMN1; SMN2ACKR3SLC1A3SLC1A2SLC1A1
SCHEMBL7709457 0.78 NOS3 (0.43) ACKR3NOS3NOS1NOS2SLC7A5
Phenylalanine SCHEMBL7906184 0.78 SLC7A5 (0.52) NOS3NOS1NOS2HDAC8SLC7A5
SCHEMBL7908862 0.78 ALDH1A1 (0.46) SMN1; SMN2ALDH1A1MAPTRAB9ALMNA
SCHEMBL6934867 0.77 LTA4H (0.39) HDAC8SLC1A3SLC1A2SLC1A1
SCHEMBL6935180 0.77 DPP4 (0.47) SLC7A5
SCHEMBL8200203 0.76 TPH1 (0.38) SLC7A5
SCHEMBL6932583 0.75 PTPN1 (0.46) SLC7A5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6362204-B1 CONTROLLING IMMUNOLOGY; ANTIINFLAMMATORY AGENTS CELLTECH THERAPEUTICS, LTD (GB) 2002-03-26 US claimed
US-6362204-B1 CONTROLLING IMMUNOLOGY; ANTIINFLAMMATORY AGENTS CELLTECH THERAPEUTICS, LTD (GB) 2002-03-26 US disclosed