Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
| ▸ | SLC7A5 | Q01650 | 4/20 | 0.39 |
| ▸ | ITGA4 | P13612 | 7/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 6/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGAV | P06756 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7709242 | 0.83 | NOS3 (0.47) | NOS3NOS1NOS2SLC7A5 | |
| SCHEMBL7709540 | 0.83 | NOS3 (0.43) | NOS3NOS1NOS2SLC7A5ITGA4 | |
| SCHEMBL7906197 | 0.82 | CCR2 (0.44) | ITGA4ITGB1ITGB3ITGAVITGA2B | |
| SCHEMBL7905098 | 0.79 | ITGB1 (0.50) | ITGA4ITGB1 | |
| SCHEMBL7706489 | 0.78 | NLRP3 (0.46) | NOS3NOS1NOS2SLC7A5ACKR3 | |
| Phenylalanine SCHEMBL7906184 | 0.78 | SLC7A5 (0.52) | NOS3NOS1NOS2SLC7A5 | |
| SCHEMBL7906194 | 0.78 | ITGA4 (0.41) | ITGA4ITGB1KMT2AITGB3ITGAV | |
| SCHEMBL7905121 | 0.77 | ITGA4 (0.42) | ITGA4ITGB1ITGB3ITGAVITGA2B | |
| SCHEMBL7896693 | 0.76 | ITGB1 (0.47) | ITGA4ITGB1ITGB3ITGAVITGA2B | |
| SCHEMBL7908666 | 0.76 | ITGB1 (0.52) | ITGA4ITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6362204-B1 | CONTROLLING IMMUNOLOGY; ANTIINFLAMMATORY AGENTS | CELLTECH THERAPEUTICS, LTD (GB) | 2002-03-26 | — | — | US | claimed |
| US-6362204-B1 | CONTROLLING IMMUNOLOGY; ANTIINFLAMMATORY AGENTS | CELLTECH THERAPEUTICS, LTD (GB) | 2002-03-26 | — | — | US | disclosed |