Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 9/20 | 0.45 |
| ▸ | BRD1 | O95696 | 4/20 | 0.41 |
| ▸ | BRPF1 | P55201 | 4/20 | 0.41 |
| ▸ | TAF1 | P21675 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 7/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7703741 | 0.84 | MDM4 (0.39) | BRD4KMT2ALMNAMAPTHTT | |
| SCHEMBL7712210 | 0.74 | MEN1 (0.38) | BRD4BRD1BRPF1TAF1MEN1 | |
| SCHEMBL30273729 | 0.69 | KMT2A (0.50) | BRD4BRD1BRPF1TAF1MEN1 | |
| SCHEMBL7703836 | 0.69 | SIGMAR1 (0.37) | MTNR1AMTNR1B | |
| SCHEMBL30273650 | 0.67 | KDM4E (0.52) | BRD4BRD1BRPF1TAF1MEN1 | |
| SCHEMBL7703797 | 0.67 | ALDH1A1 (0.44) | BRD4BRD1BRPF1MEN1KMT2A | |
| SCHEMBL7709722 | 0.67 | LMNA (0.36) | MEN1KMT2ALMNAMAPTRAB9A | |
| SCHEMBL7709632 | 0.67 | CYP1B1 (0.58) | MEN1KMT2ALMNAL3MBTL1MAPT | |
| SCHEMBL4163672 | 0.66 | MTNR1A (0.44) | MTNR1AMTNR1B | |
| SCHEMBL7709647 | 0.66 | MAPT (0.48) | BRD4BRD1BRPF1TAF1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6362181-B1 | BACTERICIDES; ENZYME INHIBITORS; ANTITUMOR AGENTS | WARNER-LAMBERT COMPANY | 2002-03-26 | — | — | US | disclosed |
| US-6177423-B1 | N-(HYDROXY OR PROTECTED HYDROXY)-BENZO(DE)ISOQUINOLINE-1,3-DIONE DERIVATIVES; BACTERIAL DNA GYRASE AND DNA TOPOISOMERASE INHIBITORS USEFUL FOR ANTIBACTERIAL AGENTS HAVING REDUCED DRUG RESISTANCE AND REDUCED SIDE EFFECTS | WARNER-LAMBERT COMPANY | 2001-01-23 | — | — | US | disclosed |