Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG known ✓ | P37231 | 5/20 | 0.41 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | TNKS | O95271 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacrylic Acid SCHEMBL7729849 | 0.98 | HTT (0.42) | GLATDP1HTTPPARGKMT2A | |
| Methacrylic Acid SCHEMBL38651194 | 0.92 | TDP1 (0.44) | GLATDP1HTTPPARGKMT2A | |
| Methacrylic Acid SCHEMBL27797874 | 0.91 | GLA (0.43) | GLATDP1HTTPPARGKMT2A | |
| Styrene SCHEMBL7851607 | 0.91 | HTT (0.37) | GLATDP1HTTPPARGKMT2A | |
| SCHEMBL15637462 | 0.88 | HTT (0.43) | TDP1HTTPPARGKMT2ALMNA | |
| SCHEMBL9397351 | 0.85 | PPARG (0.43) | GLATDP1HTTPPARGKMT2A | |
| SCHEMBL1973455 | 0.84 | PPARG (0.41) | GLATDP1HTTPPARGKMT2A | |
| Acrylic Acid SCHEMBL6279451 | 0.84 | HTT (0.42) | GLATDP1HTTPPARGKMT2A | |
| Methacrylic Acid SCHEMBL5087538 | 0.83 | PPARG (0.41) | GLATDP1HTTPPARGKMT2A | |
| Styrene SCHEMBL7851608 | 0.83 | HTT (0.38) | GLATDP1HTTPPARGKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403073-B1 | MIXTURE CONTAINING ADDITION POLYMER | L'OREAL S.A. (FR) | 2002-06-11 | — | — | US | claimed |
| EP-0869766-B1 | COMPOSITIONS FOR THE TREATMENT OF KERATINIC MATERIALS CONTAINING THE ASSOCIATION OF A POLYAMPHOLYTE POLYMER AND A CATIONIC POLYMER | OREAL (FR) | 2001-11-21 | — | — | EP | claimed |
| EP-0543473-B1 | Copolymers and their use in dispersing iron | BETZDEARBORN INC (US) | 1997-07-16 | — | — | EP | claimed |
| US-5589324-A | INTERPENETRATING POLYMER NETWORKS | INTERNATIONAL PAPER COMPANY (US) | 1996-12-31 | — | — | US | disclosed |
| US-4810624-A | COPOLYMERS OF SULFONATES AND PRIMARY AMINES | E. I. DUPONT DE NEMOURS AND COMPANY (US) | 1989-03-07 | — | — | US | disclosed |
| US-4668748-A | STYRENESULFONATES, UNSATURATED AMINES, PHOTOGRAPHIC FILMS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1987-05-26 | — | — | US | disclosed |