Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Phenolphthalein. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS known ✓ | P04818 | 2/20 | 0.67 |
| ▸ | ESR2 known ✓ | Q92731 | 1/20 | 0.67 |
| ▸ | DHFR known ✓ | P00374 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | ESR1 | P03372 | 1/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluorescein SCHEMBL1683204 | 0.84 | FTO (0.72) | MAPTMEN1KMT2ATDP1LMNA | |
| Phenolphthalein SCHEMBL10893397 | 0.82 | MAPT (0.88) | MAPTMEN1KMT2ATDP1LMNA | |
| Phenolphthalein SCHEMBL28196770 | 0.82 | MAPT (0.93) | MAPTMEN1KMT2ATDP1LMNA | |
| Phenolphthalein SCHEMBL6139696 | 0.82 | MAPT (1.00) | MAPTMEN1KMT2ATDP1LMNA | |
| Phenolphthalein SCHEMBL27670 | 0.82 | MAPT (1.00) | MAPTMEN1KMT2ATDP1LMNA | |
| Phenolphthalein SCHEMBL29362413 | 0.82 | MAPT (1.00) | MAPTMEN1KMT2ATDP1LMNA | |
| Phenolphthalein SCHEMBL676259 | 0.81 | MAPT (0.85) | MAPTMEN1KMT2ATDP1LMNA | |
| Phenolphthalein SCHEMBL11882867 | 0.80 | MAPT (0.90) | MAPTMEN1KMT2ATDP1LMNA | |
| Phenolphthalein SCHEMBL23929043 | 0.80 | MAPT (0.97) | MAPTMEN1KMT2ATDP1LMNA | |
| Phenolphthalein SCHEMBL4749522 | 0.80 | MAPT (0.97) | MAPTMEN1KMT2ATDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799896-B1 | Reagent test strip for determination of blood glucose | LIFESCAN INC (US) | 2001-09-12 | — | — | EP | claimed |
| EP-0799896-A2 | Reagent test strip for determination of blood glucose | LIFESCAN, INC. (US) | 1997-10-08 | — | — | EP | claimed |
| US-5350694-A | Composition method and device for measuring the divalent cation concentration or specific gravity of a test sample | MILES INC. (US) | 1994-09-27 | — | — | US | claimed |
| EP-0799896-B1 | Reagent test strip for determination of blood glucose | LIFESCAN INC (US) | 2001-09-12 | — | — | EP | disclosed |
| US-5972294-A | USED TO MEASURE GLUCOSE CONCENTRATION IN WHOLE BLOOD SAMPLES IN PRESENCE OF OPTICALLY VISIBLE HEMOGLOBIN; COLORIMETRIC MEASUREMENT | LIFESCAN, INC. (US) | 1999-10-26 | — | — | US | disclosed |
| US-5790627-A | Method and apparatus for observing a specimen using an X-ray microscope | RESEARCH DEVELOPMENT CORP. (JP) | 1998-08-04 | — | — | US | disclosed |
| EP-0799896-A2 | Reagent test strip for determination of blood glucose | LIFESCAN, INC. (US) | 1997-10-08 | — | — | EP | disclosed |