Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
| ▸ | MIF | P14174 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL133918 | 1.00 | KMT2A (0.33) | KMT2ANFKB1NFKB2RELATDP1 | |
| SCHEMBL206812 | 1.00 | KMT2A (0.33) | KMT2ANFKB1NFKB2RELATDP1 | |
| Sulfuric Acid SCHEMBL28494040 | 0.94 | CA12 (0.33) | KMT2ATDP1MAOAMAOBCA1 | |
| SCHEMBL2342887 | 0.86 | KMT2A (0.33) | KMT2ANFKB1NFKB2RELATDP1 | |
| SCHEMBL21359614 | 0.86 | DGAT1 (0.31) | DGAT1 | |
| SCHEMBL2823978 | 0.86 | KMT2A (0.33) | KMT2ANFKB1NFKB2RELATDP1 | |
| SCHEMBL2342888 | 0.86 | KMT2A (0.33) | KMT2ANFKB1NFKB2RELATDP1 | |
| SCHEMBL21359615 | 0.86 | DGAT1 (0.31) | DGAT1 | |
| SCHEMBL15177020 | 0.84 | KMT2A (0.33) | KMT2ANFKB1NFKB2RELATDP1 | |
| SCHEMBL14535778 | 0.84 | APLNR (0.38) | KMT2ATDP1CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220281866-A1 | 5,8-DISUBSTITUTED-[1,2,4]TRIAZOLO[1,5-A]PYRIDINYL AND 5,8-DISUBSTITUTED-IMIDAZO[1,2-A]PYRIDINE DERIVATIVES USEFUL AS INHIBITORS OF ENTEROPEPTIDASE | JANSSEN PHARMACEUTICA NV (BE) | 2022-09-08 | — | — | US | disclosed |
| US-20220033380-A1 | POLY-ADP RIBOSE POLYMERASE (PARP) INHIBITORS | Astellas Engineered Small Molecules US, Incorporated | 2022-02-03 | — | — | US | disclosed |
| US-11034670-B2 | Poly-ADP ribose polymerase (PARP) inhibitors | MITOBRIDGE, INC. (US) | 2021-06-15 | — | — | US | disclosed |
| EP-3562822-B1 | POLY-ADP RIBOSE POLYMERASE (PARP) INHIBITORS | MITOBRIDGE INC (US) | 2021-03-10 | — | — | EP | disclosed |
| US-20200071299-A1 | POLY-ADP RIBOSE POLYMERASE (PARP) INHIBITORS | Astellas Engineered Small Molecules US, Incorporated | 2020-03-05 | — | — | US | disclosed |
| WO-2019028362-A1 | INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF | DYAX CORP. (US) | 2019-02-07 | — | — | WO | disclosed |
| WO-2018125961-A1 | POLY-ADP RIBOSE POLYMERASE (PARP) INHIBITORS | MITOBRIDGE, INC. (US) | 2018-07-05 | — | — | WO | disclosed |
| US-10004702-B2 | Linear guanidine derivatives, methods of preparation and uses thereof | LEAD DISCOVERY SIENA S.R.L. (IT) | 2018-06-26 | — | — | US | disclosed |
| EP-3189060-B1 | DERIVATIVES OF MACROCYCLIC N-ARYL-2-AMINO-4-ARYL-PYRIMIDINE POLYETHERS AS INHIBITORS OF FTL3 AND JAK | PF MEDICAMENT (FR) | 2018-06-20 | — | — | EP | disclosed |
| EP-2831075-B1 | 1,3,4-OXADIAZOLE AND 1,3,4-THIADIAZOLE BETA-LACTAMASE INHIBITORS | MERCK SHARP & DOHME (US) | 2017-11-08 | — | — | EP | disclosed |
| US-20090023931-A1 | ALANINE RACEMASE CHIRAL BINAPHTHOL DERIVATIVE WITH POWERFUL HYDROGEN BOND DONOR, AND OPTICAL RESOLUTION AND OPTICAL TRANSFORMATION METHODS USING THE SAME | EWHA UNIVERSITY - INDUSTRY COLLABORATION FOUNDATION (KR) | 2009-01-22 | — | — | US | disclosed |
| US-7368605-B2 | Variously substituted derivatives of guanidine, and their use as medicines with anti-diabetes and/or anti-obesity activity | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2008-05-06 | — | — | US | disclosed |
| US-7368605-B2 | Variously substituted derivatives of guanidine, and their use as medicines with anti-diabetes and/or anti-obesity activity | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2008-05-06 | — | — | US | disclosed |
| WO-2008037463-A2 | MEANS AND METHODS OF ENHANCING DELIVERY TO BIOLOGICAL SYSTEMS | BOTTI PAOLO (CH) | 2008-04-03 | — | — | WO | disclosed |
| US-20080064687-A1 | Novel thiourea derivatives and the pharmaceutical compositions containing the same | SUH YOUNG G | 2008-03-13 | — | — | US | disclosed |
| WO-2007139569-A1 | NOVEL LAPACHONE COMPOUNDS AND METHODS OF USE THEREOF | ARQULE, INC. (US) | 2007-12-06 | — | — | WO | disclosed |
| US-20070232621-A1 | Linear dicationic terphenyls and their aza analogues as antiparasitic agents | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. | 2007-10-04 | — | — | US | disclosed |
| WO-2006065277-A2 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS | SCHERING CORPORATION (US) | 2006-06-22 | — | — | WO | disclosed |
| US-6300321-B1 | LIPOPOLYAMINES | AVENTIS PHARMA S.A. (FR) | 2001-10-09 | — | — | US | disclosed |
| US-6211181-B1 | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIALLERGENS, AND ANTIASTHMATICS | FOURNIER INDUSTRIE ET SANTE (FR) | 2001-04-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220033380-A1 | POLY-ADP RIBOSE POLYMERASE (PARP) INHIBITORS | PARP1, PARP2, PARP11 | KMT2A 1583/4885NFKB1 1445/4885NFKB2 1446/4885 |
| US-11034670-B2 | Poly-ADP ribose polymerase (PARP) inhibitors | PARP1, PARP2, PARP11 | KMT2A 1583/4885NFKB1 1445/4885NFKB2 1446/4885 |
| US-20220281866-A1 | 5,8-DISUBSTITUTED-[1,2,4]TRIAZOLO[1,5-A]PYRIDINYL AND 5,8-DISUBSTITUTED-IMIDAZO[1,2-A]PYRIDINE DERIVATIVES USEFUL AS INHIBITORS OF ENTEROPEPTIDASE | TMPRSS15, DPP8, SI | KMT2A 2608/4885NFKB1 1533/4885NFKB2 3408/4885 |
| US-20070232621-A1 | Linear dicationic terphenyls and their aza analogues as antiparasitic agents | TPMT, TYMS, DDT | KMT2A 1167/4885NFKB1 2003/4885NFKB2 2431/4885 |
| US-20080064687-A1 | Novel thiourea derivatives and the pharmaceutical compositions containing the same | TRPV1, TRPA1, TAS2R5 | KMT2A 4297/4885NFKB1 1627/4885NFKB2 1702/4885 |
| US-10004702-B2 | Linear guanidine derivatives, methods of preparation and uses thereof | GMPS, CGAS, GDA | KMT2A 4125/4885NFKB1 1681/4885NFKB2 2524/4885 |
| US-20200071299-A1 | POLY-ADP RIBOSE POLYMERASE (PARP) INHIBITORS | PARP1, PARP2, PARP11 | KMT2A 1583/4885NFKB1 1445/4885NFKB2 1446/4885 |
| US-20090023931-A1 | ALANINE RACEMASE CHIRAL BINAPHTHOL DERIVATIVE WITH POWERFUL HYDROGEN BOND DONOR, AND OPTICAL RESOLUTION AND OPTICAL TRANSFORMATION METHODS USING THE SAME | ALAD, BCAT1, BCAT2 | KMT2A 3866/4885NFKB1 3396/4885NFKB2 2855/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.