Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 4/20 | 0.42 |
| ▸ | MMP9 | P14780 | 6/20 | 0.41 |
| ▸ | MMP2 | P08253 | 4/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7956127 | 0.94 | MMP9 (0.46) | MMP9MMP2MMP1KDM4EALDH1A1 | |
| SCHEMBL7956113 | 0.89 | MMP1 (0.42) | TBXAS1MMP9MMP2MMP1KMT2A | |
| SCHEMBL7956056 | 0.85 | ALDH1A1 (0.51) | MMP9MMP2MMP1KMT2ATDP1 | |
| SCHEMBL7955824 | 0.83 | TBXAS1 (0.42) | TBXAS1MMP9MMP1KDM4EALDH1A1 | |
| SCHEMBL7955839 | 0.77 | MMP2 (0.42) | MMP9MMP2MMP1TDP1KDM4E | |
| SCHEMBL7945731 | 0.77 | MMP2 (0.57) | MMP9MMP2MMP1KMT2ATDP1 | |
| SCHEMBL7961413 | 0.75 | MMP3 (0.49) | MMP9MMP2TDP1KDM4EALDH1A1 | |
| SCHEMBL7954067 | 0.73 | MMP2 (0.64) | MMP9MMP2MMP1KMT2ATDP1 | |
| SCHEMBL1378395 | 0.71 | MMP9 (0.42) | MMP9MMP2MMP1KMT2AKDM4E | |
| SCHEMBL1376755 | 0.70 | KMT2A (0.47) | MMP9MMP2KMT2AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6277987-B1 | FOR INHIBITING MATRIX-DEGRADING METALLOPROTEINASES IN MAMMALS | NOVARTIS AG (CH) | 2001-08-21 | — | — | US | disclosed |