Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 2/20 | 0.42 |
| ▸ | MMP9 | P14780 | 2/20 | 0.42 |
| ▸ | APAF1 | O14727 | 2/20 | 0.42 |
| ▸ | MITF | O75030 | 2/20 | 0.42 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7961413 | 0.86 | MMP3 (0.49) | MMP2MMP9NPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7956127 | 0.80 | MMP9 (0.46) | MMP2MMP9ALDH1A1HSD17B10KDM4E | |
| SCHEMBL7956056 | 0.80 | ALDH1A1 (0.51) | MMP2MMP9NPSR1ALDH1A1TDP1 | |
| SCHEMBL7955836 | 0.78 | MMP2 (0.52) | MMP2MMP9SMN1; SMN2TDP1HTR1A | |
| SCHEMBL7951518 | 0.77 | MMP3 (0.46) | MMP2MMP9HTR7NPSR1ALDH1A1 | |
| SCHEMBL7945733 | 0.77 | PGR (0.43) | MMP2MMP9ALDH1A1TDP1HSD17B10 | |
| SCHEMBL7956113 | 0.76 | MMP1 (0.42) | MMP2MMP9ALDH1A1HSD17B10KDM4E | |
| SCHEMBL7959175 | 0.75 | MMP2 (0.63) | MMP2MMP9HTR1AMMP1MMP14 | |
| SCHEMBL7955824 | 0.74 | TBXAS1 (0.42) | MMP9ALDH1A1TSHRKDM4EMAPT | |
| SCHEMBL7952565 | 0.74 | LMNA (0.55) | MMP2MMP9ALDH1A1TDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6277987-B1 | FOR INHIBITING MATRIX-DEGRADING METALLOPROTEINASES IN MAMMALS | NOVARTIS AG (CH) | 2001-08-21 | — | — | US | disclosed |