Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 3/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.35 |
| ▸ | NPY1R | P25929 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7953789 | 0.80 | USP2 (0.56) | DRD2HTR1AKDM4ELMNAMAPT | |
| SCHEMBL7953787 | 0.78 | KDM4E (0.37) | DRD2SLC6A4KDM4EALDH1A1LMNA | |
| SCHEMBL7964964 | 0.78 | HTR1A (0.47) | DRD2SLC6A4HTR1AHTR7 | |
| SCHEMBL8145712 | 0.73 | DRD2 (0.48) | DRD2SLC6A4ROCK2HTR1AHTR7 | |
| SCHEMBL7963100 | 0.70 | SLC6A1 (0.34) | DRD2SLC6A4HTR1AKDM4ELMNA | |
| SCHEMBL7962999 | 0.68 | OPRL1 (0.40) | DRD2HTR1A | |
| SCHEMBL7966953 | 0.67 | OPRL1 (0.39) | HTR1AALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL13728399 | 0.67 | CYP11B2 (0.42) | DRD2SLC6A4HTR1AKDM4ELMNA | |
| SCHEMBL7963306 | 0.66 | MAPK1 (0.40) | DRD2SLC6A4KDM4EALDH1A1MAPK1 | |
| SCHEMBL7967096 | 0.66 | TUBB4A (0.38) | HTR7ADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| WO-2000006166-A1 | 5-HT1F ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |