Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963021 | 0.86 | ALDH1A1 (0.43) | ALDH1A1KMT2AMEN1LMNADRD3 | |
| SCHEMBL7962701 | 0.84 | LTA4H (0.36) | ALDH1A1KMT2AMEN1LMNADRD3 | |
| SCHEMBL7962748 | 0.84 | PDE10A (0.39) | MAPTKMT2AMEN1DRD3DRD2 | |
| SCHEMBL7962210 | 0.82 | TP53 (0.56) | ALDH1A1MAPTKMT2AMEN1TP53 | |
| SCHEMBL7962207 | 0.81 | ALDH1A1 (0.43) | ALDH1A1NPC1MAPTRAB9AKMT2A | |
| SCHEMBL7965119 | 0.79 | OPRM1 (0.39) | ALDH1A1NPC1MAPTRAB9AKMT2A | |
| SCHEMBL7953348 | 0.79 | MEN1 (0.47) | ALDH1A1KMT2AMEN1LMNADRD3 | |
| Sulfuric Acid SCHEMBL7968961 | 0.78 | DRD3 (0.37) | DRD3DRD2FAAHHTR1A | |
| SCHEMBL7963401 | 0.78 | ADRB2 (0.33) | KMT2AMEN1LMNATP53OPRM1 | |
| SCHEMBL7964943 | 0.76 | LTA4H (0.33) | DRD3DRD2OPRM1OPRL1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| WO-2000006166-A1 | 5-HT1F ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |