Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7962207 | 0.75 | ALDH1A1 (0.43) | SMN1; SMN2 | |
| SCHEMBL7965112 | 0.74 | LMNA (0.39) | SMN1; SMN2NPSR1 | |
| SCHEMBL7966053 | 0.73 | MAPT (0.36) | — | |
| SCHEMBL7962696 | 0.73 | LTA4H (0.35) | SMN1; SMN2 | |
| SCHEMBL7966055 | 0.73 | LMNA (0.32) | — | |
| Fumaric Acid SCHEMBL7966209 | 0.72 | MAPT (0.38) | NPSR1 | |
| Fumaric Acid SCHEMBL7966218 | 0.72 | MAPT (0.38) | NPSR1 | |
| SCHEMBL7962741 | 0.71 | PDE10A (0.42) | PDE2APDE10A | |
| Sulfuric Acid SCHEMBL7968955 | 0.71 | THRB (0.36) | — | |
| Heptanoate SCHEMBL7966354 | 0.71 | LTA4H (0.38) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| WO-2000006166-A1 | 5-HT1F ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |