Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.36 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.33 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.32 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 5/20 | 0.33 |
| ▸ | PPARA | Q07869 | 5/20 | 0.33 |
| ▸ | PTGES | O14684 | 4/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL7966218 | 1.00 | MAPT (0.38) | MAPTPOLBMEN1KMT2AALDH1A1 | |
| Fumaric Acid SCHEMBL7966212 | 0.84 | ABCB1 (0.51) | MAPTMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL7966027 | 0.79 | MAPT (0.37) | MAPTPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL7963392 | 0.79 | ADRB2 (0.35) | MEN1KMT2ALMNANPSR1HCRTR1 | |
| SCHEMBL7962207 | 0.76 | ALDH1A1 (0.43) | MAPTPOLBMEN1KMT2AALDH1A1 | |
| Salicylic Acid SCHEMBL8133872 | 0.76 | ABCB1 (0.32) | MAPTALDH1A1HPGDMAPK1LMNA | |
| SCHEMBL7965112 | 0.75 | LMNA (0.39) | MAPTKMT2AALDH1A1HPGDMAPK1 | |
| SCHEMBL7962696 | 0.74 | LTA4H (0.35) | MAPTMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL7964944 | 0.74 | MEN1 (0.30) | MEN1KMT2A | |
| Lactic Acid SCHEMBL7966052 | 0.72 | SMN1; SMN2 (0.31) | NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |