SCHEMBL7964944

SCHEMBL7964944

Cc1cc(OCCC(O)N2CCC(O)(c3cnc4ccccc4n3)CC2)c2cc(C)oc2c1

nearest known ligand 0.30

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7964941 0.84 CCR1 (0.45) MEN1KMT2A
SCHEMBL7964943 0.83 LTA4H (0.33)
SCHEMBL7965112 0.78 LMNA (0.39) KMT2A
SCHEMBL7963392 0.77 ADRB2 (0.35) MEN1KMT2A
SCHEMBL7962207 0.76 ALDH1A1 (0.43) MEN1KMT2A
SCHEMBL7962696 0.74 LTA4H (0.35) MEN1KMT2A
Fumaric Acid SCHEMBL7966209 0.74 MAPT (0.38) MEN1KMT2A
Fumaric Acid SCHEMBL7966218 0.74 MAPT (0.38) MEN1KMT2A
SCHEMBL7962741 0.72 PDE10A (0.42)
Salicylic Acid SCHEMBL8133872 0.71 ABCB1 (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6242450-B1 SUBSTITUTED PIPERIDINES ELI LILLY AND COMPANY 2001-06-05 US disclosed
WO-2000006166-A1 5-HT1F ANTAGONISTS ELI LILLY AND COMPANY (US) 2000-02-10 WO disclosed
EP-0976746-A1 5-HT1F antagonists ELI LILLY AND COMPANY (US) 2000-02-02 EP disclosed