SCHEMBL8014288

SCHEMBL8014288

CCn1ncc(C(=O)c2cc(C)c3c(c2C)C2(CCS3([O-])[O-])OCCO2)c1O.[Na+].[Na+]

nearest known ligand 0.31

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 2/20 0.31
SMN1; SMN2 Q16637 2/20 0.31
ALDH1A1 P00352 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP2C19 P33261 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8014291 0.88 RAB9A (0.32) RAB9ASMN1; SMN2ALDH1A1CYP1A2CYP2C19
SCHEMBL8459595 0.88 RAB9A (0.32) RAB9ASMN1; SMN2ALDH1A1CYP1A2CYP2C19
SCHEMBL8014294 0.88 RAB9A (0.32) RAB9ASMN1; SMN2ALDH1A1CYP1A2CYP2C19
SCHEMBL8128408 0.82 RAB9A (0.35) RAB9ASMN1; SMN2ALDH1A1CYP1A2CYP2C19
SCHEMBL8455943 0.79 RAB9A (0.32) RAB9ASMN1; SMN2ALDH1A1CYP1A2CYP2C19
SCHEMBL6721441 0.76 SMN1; SMN2 (0.34) RAB9ASMN1; SMN2ALDH1A1CYP1A2CYP2C19
SCHEMBL6732599 0.73 SMN1; SMN2 (0.35) RAB9ASMN1; SMN2ALDH1A1CYP1A2CYP2C19
SCHEMBL7842848 0.69 SMN1; SMN2 (0.37) RAB9ASMN1; SMN2ALDH1A1CYP1A2CYP2C19
SCHEMBL8132272 0.69 SPR (0.39) RAB9ASMN1; SMN2ALDH1A1CYP1A2CYP2C19
SCHEMBL8130838 0.69 TNF (0.32) RAB9ASMN1; SMN2ALDH1A1CYP1A2CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0968649-A1 Adjuvants for novel dry herbicide formulations E.I. DU PONT DE NEMOURS AND COMPANY (US) 2000-01-05 EP claimed
EP-0968649-A1 Adjuvants for novel dry herbicide formulations E.I. DU PONT DE NEMOURS AND COMPANY (US) 2000-01-05 EP disclosed