Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Thiourea. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Urea SCHEMBL27515739 | 0.80 | — | — | |
| Guanidine SCHEMBL2364149 | 0.77 | — | — | |
| Acetamide SCHEMBL27363690 | 0.74 | — | — | |
| Nitrous Acid SCHEMBL17180228 | 0.74 | — | — | |
| Nitrous Acid SCHEMBL19743130 | 0.73 | ALDH1A1 (0.75) | — | |
| Nitrous Acid SCHEMBL8933907 | 0.73 | — | — | |
| Nitrous Acid SCHEMBL11219505 | 0.73 | ALDH1A1 (1.00) | — | |
| Nitrous Acid SCHEMBL341 | 0.73 | — | — | |
| Nitrous Acid SCHEMBL9079679 | 0.73 | ALDH1A1 (1.00) | — | |
| Nitrous Acid SCHEMBL1331277 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0655430-B1 | Gassed emulsion explosives | SASOL CHEMICAL IND (ZA) | 2000-09-06 | — | — | EP | disclosed |
| US-5608185-A | Method of reducing nitrogen oxide fumes in blasting | DYNO NOBEL INC. (US) | 1997-03-04 | — | — | US | disclosed |
| US-5458707-A | Polyisobutylene succinic anhydride | SASOL CHEMICAL INDUSTRIES (PROPRIETARY) LIMITED (ZA) | 1995-10-17 | — | — | US | disclosed |
| EP-0655430-A1 | Gassed emulsion explosives | SASOL CHEMICAL INDUSTRIES (PROPRIETARY) LIMITED (ZA) | 1995-05-31 | — | — | EP | disclosed |
| EP-0487246-B1 | Stabilized emulsion explosive | DYNO NOBEL INC (US) | 1995-03-15 | — | — | EP | disclosed |
| EP-0438896-B1 | Shock-resistant, low density emulsion explosive | DYNO NOBEL INC (US) | 1994-11-09 | — | — | EP | disclosed |
| EP-0448379-B1 | Surfactant for gassed emulsion explosive | DYNO NOBEL INC (US) | 1994-11-02 | — | — | EP | disclosed |
| US-5159153-A | Water immiscible organic fuel, oxidizer, emulsifier, urea | DYNO NOBEL INC. | 1992-10-27 | — | — | US | disclosed |
| EP-0487246-A1 | Stabilized emulsion explosive | DYNO NOBEL INC. (US) | 1992-05-27 | — | — | EP | disclosed |
| US-5076867-A | Dissolving surfactant in liquid fuel, adding to ammonium nitrate prills, blending with emulsion to form explosive | DYNO NOBEL INC. | 1991-12-31 | — | — | US | disclosed |
| EP-0460952-A2 | Emulsion that is compatible with reactive sulfide/pyrite ores | DYNO NOBEL INC. (US) | 1991-12-11 | — | — | EP | disclosed |
| EP-0448379-A1 | Surfactant for gassed emulsion explosive | DYNO NOBEL INC. (US) | 1991-09-25 | — | — | EP | disclosed |
| EP-0438896-A2 | Shock-resistant, low density emulsion explosive | DYNO NOBEL INC. (US) | 1991-07-31 | — | — | EP | disclosed |
| US-5017251-A | Shock-resistant, low density emulsion explosive | IRECO INCORPORATED (US) | 1991-05-21 | — | — | US | disclosed |
| US-4960475-A | Surfactant for gassed emulsion explosive | DYNO NOBEL INC. | 1990-10-02 | — | — | US | disclosed |
| US-4500369-A | AMMONIUM NITRATE, CALCIUM NITRATE, CRYSTALLIZATION TEMPERATURE ANDDENSITY REDUCING AGENTS, EMULSIFIERS, OILS OR WAXES | NORSK HYDRO A.S. (NO) | 1985-02-19 | — | — | US | disclosed |