SCHEMBL8078591

SCHEMBL8078591

C[Si](C)(C)c1cccc2c1oc1ccccc12

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 3/20 0.44
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
CYP2C19 P33261 1/20 0.42
AHR P35869 1/20 0.42
ALDH1A1 P00352 4/20 0.41
KDM4E B2RXH2 4/20 0.41
MAOA P21397 3/20 0.41
NPC1 O15118 1/20 0.41
LMNA P02545 1/20 0.41
RAB9A P51151 1/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
MAPT P10636 2/20 0.40
PRKDC P78527 2/20 0.40
PIK3CD O00329 1/20 0.40
PIK3CB P42338 1/20 0.40
LIMK1 P53667 1/20 0.40
DRD4 P21917 1/20 0.39
GLA P06280 1/20 0.39
CYP3A4 P08684 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17132728 0.85 IDO1 (0.41) AHRNPC1
SCHEMBL22373672 0.82 ALOX5 (0.40) ALOX5MEN1KMT2ACYP2C19AHR
SCHEMBL15638027 0.82 ALOX5 (0.40) ALOX5MEN1KMT2ACYP2C19AHR
SCHEMBL16273148 0.80 ALDH1A1 (0.41) MEN1KMT2AALDH1A1KDM4ENPC1
SCHEMBL16261664 0.80 KDM4E (0.41) MEN1KMT2AALDH1A1KDM4ENPC1
SCHEMBL20172790 0.80 ALOX5 (0.37) ALOX5MEN1KMT2ACYP2C19AHR
SCHEMBL15363824 0.79 ALOX5 (0.41) ALOX5MEN1KMT2ACYP2C19AHR
SCHEMBL18065848 0.79 ALOX5 (0.41) ALOX5MEN1KMT2ACYP2C19AHR
SCHEMBL16273149 0.79 ESR2 (0.39) MEN1KMT2AAHRALDH1A1KDM4E
SCHEMBL23051444 0.77 MEN1 (0.38) ALOX5MEN1KMT2ACYP2C19AHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230210004-A1 MATERIALS FOR ELECTRONIC DEVICES MERCK PATENT GMBH (DE) 2023-06-29 US disclosed
US-20220162236-A1 SILYLATIONS OF AROMATIC SUBSTRATES WITH BASE-ACTIVATED ORGANOSILANES CALIFORNIA INSTITUTE OF TECHNOLOGY 2022-05-26 US disclosed
US-11230520-B2 Silylations of aromatic substrates with base-activated organosilanes CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2022-01-25 US disclosed
CN-108409518-B Transition metal-free reductive cleavage of aromatic C-O, C-N and C-S bonds by reactive silanes 加州理工学院 2021-10-12 CN disclosed
US-20210122701-A1 SILYLATIONS OF AROMATIC SUBSTRATES WITH BASE-ACTIVATED ORGANOSILANES CALIFORNIA INSTITUTE OF TECHNOLOGY 2021-04-29 US disclosed
CN-107253967-B Transition metal-free silylation of aromatic compounds 加州理工学院 2021-03-30 CN disclosed
US-10927065-B2 Silylations of aromatic substrates with base-activated organosilanes CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2021-02-23 US disclosed
US-10836723-B2 Method for synthesizing sodium 2,2,6,6-tetramethylpiperidides KOBELCO ECO-SOLUTIONS CO., LTD. (JP) 2020-11-17 US disclosed
CN-108409518-A By active silane to the C-O keys of aromatics, C-N keys and C-S keys without transition metal reductive cleavage 加州理工学院 2018-08-17 CN disclosed
US-20180155271-A1 SILYLATIONS OF AROMATIC SUBSTRATES WITH BASE-ACTIVATED ORGANOSILANES CALIFORNIA INSTITUTE OF TECHNOLOGY 2018-06-07 US disclosed
US-20160176772-A1 SILYLATION OF AROMATIC HETEROCYCLES BY DISILANES USING POTASSIUM ALKOXIDE CATALYSTS CALIFORNIA INSTITUTE OF TECHNOLOGY 2016-06-23 US disclosed
US-20160164002-A1 MATERIALS FOR ELECTRONIC DEVICES MERCK PATENT GMBH (DE) 2016-06-09 US disclosed
US-9309269-B2 Transition-metal-free silylation of aromatic compounds CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2016-04-12 US disclosed
US-20150166579-A1 TRANSITION-METAL-FREE SILYLATION OF AROMATIC COMPOUNDS CALIFORNIA INST OF TECHN (US) 2015-06-18 US disclosed
US-9000167-B2 Transition-metal-free silylation of aromatic compounds CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2015-04-07 US disclosed
WO-2014055586-A1 TRANSITION-METAL FREE REDUCTIVE CLEAVAGE OF AROMATIC C-O, C-N, AND C-S BONDS BY ACTIVATED SILANES CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2014-04-10 WO disclosed
WO-2014055587-A1 TRANSITION-METAL-FREE SILYLATION OF AROMATIC COMPOUNDS CALIFORNIA INSTITUTE OF TECHONOLGY (US) 2014-04-10 WO disclosed
US-6034211-A β-sheet nucleating peptidomimetics KELLY JEFFERY W (US) 2000-03-07 US disclosed
WO-1997046547-A1 β-SHEET NUCLEATING PEPTIDOMIMETICS THE TEXAS A & M UNIVERSITY SYSTEM (US) 1997-12-11 WO disclosed
US-4513137-A Iodonium salts THE UNIVERSITY OF AKRON (US) 1985-04-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10927065-B2 Silylations of aromatic substrates with base-activated organosilanes TYR, DDC, TPST2 ALOX5 3777/4885MEN1 2928/4885KMT2A 794/4885
US-20180155271-A1 SILYLATIONS OF AROMATIC SUBSTRATES WITH BASE-ACTIVATED ORGANOSILANES TYR, DDC, TPST2 ALOX5 3777/4885MEN1 2928/4885KMT2A 794/4885
US-11230520-B2 Silylations of aromatic substrates with base-activated organosilanes TYR, DDC, TPST2 ALOX5 3777/4885MEN1 2928/4885KMT2A 794/4885
US-20150166579-A1 TRANSITION-METAL-FREE SILYLATION OF AROMATIC COMPOUNDS TST, TPR, TYR ALOX5 3383/4885MEN1 1381/4885KMT2A 272/4885
US-20220162236-A1 SILYLATIONS OF AROMATIC SUBSTRATES WITH BASE-ACTIVATED ORGANOSILANES TYR, DDC, TPST2 ALOX5 3777/4885MEN1 2928/4885KMT2A 794/4885
US-20230210004-A1 MATERIALS FOR ELECTRONIC DEVICES EPHB3, EPHA3, EPHB4 ALOX5 3227/4885MEN1 1322/4885KMT2A 864/4885
US-20160176772-A1 SILYLATION OF AROMATIC HETEROCYCLES BY DISILANES USING POTASSIUM ALKOXIDE CATALYSTS DDC, KCNH3, KCNN2 ALOX5 3495/4885MEN1 1144/4885KMT2A 111/4885
US-20210122701-A1 SILYLATIONS OF AROMATIC SUBSTRATES WITH BASE-ACTIVATED ORGANOSILANES TYR, DDC, TPST2 ALOX5 3777/4885MEN1 2928/4885KMT2A 794/4885
US-20160164002-A1 MATERIALS FOR ELECTRONIC DEVICES EPX, EFNA1, GPX4 ALOX5 3140/4885MEN1 2161/4885KMT2A 1971/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.