SCHEMBL809238

SCHEMBL809238

O=C([O-])C(Cl)COCc1ccccc1.[Na+]

nearest known ligand 0.48

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CA1 known ✓ P00915 5/20 0.47
CA2 known ✓ P00918 3/20 0.47
CA4 known ✓ P22748 1/20 0.40
SLC1A1 P43005 1/20 0.48
CA7 P43166 3/20 0.47
CA9 Q16790 3/20 0.47
TSHR P16473 1/20 0.45
ALDH1A1 P00352 2/20 0.44
FOLH1 Q04609 1/20 0.43
TACR1 P25103 2/20 0.42
MAPK1 P28482 1/20 0.42
ALPL P05186 1/20 0.40
POLB P06746 1/20 0.40
ALPG P10696 1/20 0.40
HTT P42858 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Potassium Ion SCHEMBL809092 0.97 SLC1A1 (0.48) SLC1A1CA1CA2CA7CA9
SCHEMBL809052 0.84 SLC1A1 (0.55) SLC1A1CA1CA2CA7CA9
SCHEMBL809091 0.83 SLC1A1 (0.54) SLC1A1CA1CA2CA7CA9
SCHEMBL5551683 0.83 ALDH1A1 (0.52) SLC1A1CA1CA2CA7CA9
Hydrochloric Acid SCHEMBL5551687 0.83 SLC1A1 (0.54) SLC1A1CA1CA2CA7CA9
SCHEMBL809237 0.83 SLC1A1 (0.54) SLC1A1CA1CA2CA7CA9
SCHEMBL11025934 0.81 ALDH1A1 (0.55) SLC1A1CA1CA2CA7CA9
Potassium Ion SCHEMBL6442452 0.81 SMN1; SMN2 (0.44) SLC1A1CA1CA2CA7CA9
SCHEMBL31532269 0.79 ALDH1A1 (0.47) SLC1A1CA1CA2CA7CA9
SCHEMBL31532270 0.79 ALDH1A1 (0.47) SLC1A1CA1CA2CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1588998-B1 A process for the preparation of 2-chloro-3-(phenylmethoxy)propionic acid potassium salt BRACCO IMAGING SPA (IT) 2011-11-30 EP claimed
JP-4476486-B2 2010-06-09 JP claimed
EP-1588998-A1 A process for the preparation of 2-chloro-3-(phenylmethoxy)propionic acid potassium salt Bracco Imaging S.p.A. (IT) 2005-10-26 EP claimed
JP-2002520305-A 2002-07-09 JP claimed
EP-1095009-A2 A PROCESS FOR THE PREPARATION OF 4-CARBOXY- 5,8,11- TRIS(CARBOXYMETHYL)- 1-PHENYL- 2-OXA- 5,8,11- TRIAZATRIDECAN- 13-OIC ACID Bracco Imaging S.p.A. (IT) 2001-05-02 EP claimed
US-6162947-A Process for the preparation of 4-carboxy-5, 8,11-tris (carboxymethyl)-phenyl-2-oxa-5, 8 11-triazatridecan DIBRA S.P.A. (IT) 2000-12-19 US claimed
WO-2000002847-A2 A PROCESS FOR THE PREPARATION OF 4-CARBOXY- 5,8,11- TRIS(CARBOXYMETHYL)- 1-PHENYL- 2-OXA- 5,8,11- TRIAZATRIDECAN- 13-OIC ACID BRACCO S.P.A. (IT) 2000-01-20 WO claimed
EP-1588998-B1 A process for the preparation of 2-chloro-3-(phenylmethoxy)propionic acid potassium salt BRACCO IMAGING SPA (IT) 2011-11-30 EP disclosed
EP-1588998-A1 A process for the preparation of 2-chloro-3-(phenylmethoxy)propionic acid potassium salt Bracco Imaging S.p.A. (IT) 2005-10-26 EP disclosed
EP-1095009-A2 A PROCESS FOR THE PREPARATION OF 4-CARBOXY- 5,8,11- TRIS(CARBOXYMETHYL)- 1-PHENYL- 2-OXA- 5,8,11- TRIAZATRIDECAN- 13-OIC ACID Bracco Imaging S.p.A. (IT) 2001-05-02 EP disclosed
US-6162947-A Process for the preparation of 4-carboxy-5, 8,11-tris (carboxymethyl)-phenyl-2-oxa-5, 8 11-triazatridecan DIBRA S.P.A. (IT) 2000-12-19 US disclosed
WO-2000002847-A2 A PROCESS FOR THE PREPARATION OF 4-CARBOXY- 5,8,11- TRIS(CARBOXYMETHYL)- 1-PHENYL- 2-OXA- 5,8,11- TRIAZATRIDECAN- 13-OIC ACID BRACCO S.P.A. (IT) 2000-01-20 WO disclosed
US-5403572-A Macrocyclic polyaza compounds containing 5 or 6 membered rings, process for producing them and pharmaceutical media containing them SCHERING AKTIENGESELLSCHAFT (DE) 1995-04-04 US disclosed
EP-0325762-B1 Macrocyclic chelating agents and chelates thereof BRACCO SPA (IT) 1995-03-22 EP disclosed
US-5334371-A Marcocyclic polyaza bicyclo compounds containing 5 or 6 membered rings, and method for MRI SCHERING AKTIENGESELLSCHAFT (DE) 1994-08-02 US disclosed
US-5132409-A Derivatives of 1,4,7,10-Tetraazacyclododecane BRACCO INDUSTRIA CHIMICA S.P.A. (IT) 1992-07-21 US disclosed
EP-0440606-A1 MACROCYCLIC CHELATING AGENTS AND CHELATES THEREOF BRACCO INDUSTRIA CHIMICA Società per Azioni (IT) 1991-08-14 EP disclosed
EP-0325762-A1 Macrocyclic chelating agents and chelates thereof BRACCO S.p.A. (IT) 1989-08-02 EP disclosed
WO-1989005802-A1 MACROCYCLIC CHELATING AGENTS AND CHELATES THEREOF BRACCO INDUSTRIA CHIMICA S.P.A. (IT) 1989-06-29 WO disclosed