Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 3/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.38 |
| ▸ | ACACB | O00763 | 2/20 | 0.37 |
| ▸ | ELANE | P08246 | 2/20 | 0.36 |
| ▸ | PPARA | Q07869 | 4/20 | 0.36 |
| ▸ | PPARG | P37231 | 3/20 | 0.36 |
| ▸ | FABP2 | P12104 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8235372 | 0.81 | PRSS1 (0.61) | PRSS1PRSS2PRSS3ITGB3ITGA2B | |
| SCHEMBL15508820 | 0.81 | TRPV1 (0.45) | MAPTRAB9ATRPV1 | |
| SCHEMBL1711303 | 0.78 | MAPT (0.38) | ACACBELANEPPARAPPARGFABP2 | |
| SCHEMBL2031463 | 0.78 | MAPT (0.61) | ACACBELANEPPARAPPARGFABP2 | |
| SCHEMBL26746 | 0.78 | SLC6A2 (0.44) | ACACBELANEPPARAPPARGFABP2 | |
| SCHEMBL7769320 | 0.77 | ELANE (0.43) | ACACBELANEPPARAPPARGFABP2 | |
| SCHEMBL20076975 | 0.76 | ELANE (0.60) | ELANEPPARAPPARGFABP2SLC22A12 | |
| SCHEMBL27712194 | 0.75 | SLC6A2 (0.42) | ACACBELANEPPARAPPARGFABP2 | |
| SCHEMBL18644564 | 0.75 | NOS3 (0.39) | PRSS1PRSS2PRSS3MAPTST14 | |
| SCHEMBL22897523 | 0.75 | FURIN (0.39) | ACACBELANEPPARAPPARGFABP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8207209-B2 | Methods of inhibiting viral infection | FUNCTIONAL GENETICS, INC. (US) | 2012-06-26 | — | — | US | disclosed |
| US-20120035198-A1 | Antiviral Compounds and Methods of Using Thereof | AMAN MOHAMMAD JAVAD (US) | 2012-02-09 | — | — | US | disclosed |
| US-7999001-B2 | Antiviral compounds and methods of using thereof | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 2011-08-16 | — | — | US | disclosed |
| US-20110086877-A1 | Small Molecule Inhibitors of Botulinum Neurotoxins | BAVARI SINA | 2011-04-14 | — | — | US | disclosed |
| US-7825154-B2 | Small molecule inhibitors of botulinum neurotoxins | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 2010-11-02 | — | — | US | disclosed |
| US-20090170890-A1 | METHOHDS OF INHIBITING VIRAL INFECTION | FUNCTIONAL GENETICS, INC. (US) | 2009-07-02 | — | — | US | disclosed |
| US-20070112048-A1 | Broad Spectrum Antibacterial Compounds | U.S. ARMY MEDICAL RESEARCH AND MATERIEL COMMAND | 2007-05-17 | — | — | US | disclosed |
| US-20070112049-A1 | nonpeptidic inhibitors of Botulinum neurotoxin A metalloprotease activity, such as 2-[4-(4-carbamimidoylphenoxy)phenyl]-1H-indole-5-carboximidamide, used for treating, inhibiting or preventing intoxication caused by bacteria | ARMY, UNITED STATES | 2007-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070112048-A1 | Broad Spectrum Antibacterial Compounds | MPO, CAT, LPO | PRSS1 2634/4885PRSS2 2758/4885PRSS3 2711/4885 |
| US-20120035198-A1 | Antiviral Compounds and Methods of Using Thereof | ZC3HAV1, MAVS, ZC3HAV1L | PRSS1 548/4885PRSS2 558/4885PRSS3 568/4885 |
| US-20070112049-A1 | nonpeptidic inhibitors of Botulinum neurotoxin A metalloprotease activity, such as 2-[4-(4-carbamimidoylphenoxy)phenyl]-1H-indole-5-carboximidamide, used for treating, inhibiting or preventing intoxication caused by bacteria | ACHE, CTRL, MMP2 | PRSS1 78/4885PRSS2 151/4885PRSS3 125/4885 |
| US-20110086877-A1 | Small Molecule Inhibitors of Botulinum Neurotoxins | ACHE, MMP2, TIMP3 | PRSS1 94/4885PRSS2 189/4885PRSS3 158/4885 |
| US-20090170890-A1 | METHOHDS OF INHIBITING VIRAL INFECTION | CASP8, CASP1, CASP3 | PRSS1 46/4885PRSS2 114/4885PRSS3 75/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.