Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.52 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA3 | P07451 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | CA6 | P23280 | 1/20 | 0.48 |
| ▸ | CA5A | P35218 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12388116 | 0.85 | CA12 (0.56) | CA2ALDH1A1CA1CA12CA9 | |
| Methylphenylsulfone SCHEMBL28158010 | 0.78 | PTGS2 (0.58) | HTR6PSIP1CA2ALDH1A1CA1 | |
| Methylphenylsulfone SCHEMBL78253 | 0.77 | PTGS2 (0.62) | HTR6PSIP1CA2ALDH1A1CA1 | |
| Methylphenylsulfone SCHEMBL1332357 | 0.77 | PTGS2 (0.62) | HTR6PSIP1CA2ALDH1A1CA1 | |
| SCHEMBL56111 | 0.76 | GAA (0.59) | CA2ALDH1A1CA1TDP1CA12 | |
| Methylphenylsulfone SCHEMBL5499087 | 0.74 | PTGS2 (0.60) | HTR6PSIP1CA2ALDH1A1CA1 | |
| (Phenylsulfonyl)Benzene SCHEMBL10870153 | 0.74 | HTR6 (0.82) | HTR6PSIP1CA2ALDH1A1CA1 | |
| SCHEMBL8264434 | 0.74 | KMT2A (0.53) | ALDH1A1SMN1; SMN2KDM4ELMNAMAPT | |
| SCHEMBL486856 | 0.72 | HTR6 (0.52) | HTR6PSIP1CA2ALDH1A1CA1 | |
| SCHEMBL12792396 | 0.72 | ALDH1A1 (0.62) | HTR6PSIP1CA2ALDH1A1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170137441-A1 | Piperidine Derivatives And Compositions For the Inhibition Of Nicotinamide Phosphoribosyltransferase (NAMPT) | VALO EARLY DISCOVERY, INC. | 2017-05-18 | — | — | US | disclosed |
| EP-2428508-B9 | DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND | ASTELLAS PHARMA INC (JP) | 2016-04-20 | — | — | EP | disclosed |
| US-20160031890-A1 | NOVEL METHODS, COMPOUNDS, AND COMPOSITIONS FOR INHIBITION OF ROS | GRUENEBERG, Dorre A. | 2016-02-04 | — | — | US | disclosed |
| US-20160002188-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR INHIBITION OF FASN | FORMA THERAPEUTICS, INC. | 2016-01-07 | — | — | US | disclosed |
| US-9169209-B2 | Compounds and compositions for the inhibition of NAMPT | FORMA TM, LLC (US) | 2015-10-27 | — | — | US | disclosed |
| WO-2015087352-A1 | A PROCESS FOR THE SYNTHESIS OF ARYL SULFONES | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2015-06-18 | — | — | WO | disclosed |
| US-20140275057-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | Valo Health, LLC | 2014-09-18 | — | — | US | disclosed |
| US-20110190409-A1 | LADDER POLYMERS WITH INSTRINSIC MICROPOROSITY AND PROCESS FOR PRODUCTION THEREOF | NATIONAL RESEARCH COUNCIL OF CANADA (CA) | 2011-08-04 | — | — | US | disclosed |
| US-20100261788-A1 | Inhibition of Bid-Induced Cell-Death Using Small Organic Molecules | THE BURNHAM INSTITUTE | 2010-10-14 | — | — | US | disclosed |
| WO-2004078756-A2 | JNK INHIBITORS | EISAI CO., LTD. (JP) | 2004-09-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261788-A1 | Inhibition of Bid-Induced Cell-Death Using Small Organic Molecules | BID, BAD, TMBIM6 | HTR6 480/4885PSIP1 2060/4885CA2 3616/4885 |
| US-20160031890-A1 | NOVEL METHODS, COMPOUNDS, AND COMPOSITIONS FOR INHIBITION OF ROS | ROS1, NOX4, NOX1 | HTR6 4546/4885PSIP1 3479/4885CA2 707/4885 |
| US-20140275057-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | NAMPT, NNMT, NAPRT | HTR6 1886/4885PSIP1 3479/4885CA2 2065/4885 |
| US-20110190409-A1 | LADDER POLYMERS WITH INSTRINSIC MICROPOROSITY AND PROCESS FOR PRODUCTION THEREOF | CCR3, CNOT9, AR | HTR6 3141/4885PSIP1 3375/4885CA2 3773/4885 |
| US-20160002188-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR INHIBITION OF FASN | FASN, FABP1, SCD | HTR6 2802/4885PSIP1 4068/4885CA2 3923/4885 |
| US-20170137441-A1 | Piperidine Derivatives And Compositions For the Inhibition Of Nicotinamide Phosphoribosyltransferase (NAMPT) | NAMPT, NAPRT, NNMT | HTR6 2299/4885PSIP1 2762/4885CA2 2155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.