Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Fluorescein. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS known ✓ | P04818 | 1/20 | 0.57 |
| ▸ | ESR2 known ✓ | Q92731 | 1/20 | 0.57 |
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.50 |
| ▸ | FTO | Q9C0B1 | 8/20 | 0.94 |
| ▸ | MAPT | P10636 | 4/20 | 0.94 |
| ▸ | MEN1 | O00255 | 4/20 | 0.94 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.94 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.94 |
| ▸ | HTT | P42858 | 2/20 | 0.94 |
| ▸ | HPGD | P15428 | 2/20 | 0.94 |
| ▸ | RECQL | P46063 | 2/20 | 0.94 |
| ▸ | BLM | P54132 | 2/20 | 0.94 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.94 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.94 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.94 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.94 |
| ▸ | LMNA | P02545 | 3/20 | 0.66 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.66 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluorescein SCHEMBL27654958 | 0.97 | FTO (0.94) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL29388667 | 0.97 | FTO (1.00) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL29371199 | 0.97 | FTO (1.00) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL3645090 | 0.97 | FTO (1.00) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL16533 | 0.97 | FTO (1.00) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL30272223 | 0.97 | FTO (1.00) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL538249 | 0.96 | FTO (0.97) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL21410711 | 0.96 | FTO (0.97) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL17867543 | 0.96 | FTO (0.97) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL21358817 | 0.96 | FTO (0.97) | FTOMAPTMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107540823-A | One kind is based on S, the strong two-photon absorption conjugated polymer of S dioxydibenze bithiophene units and preparation method and application | 华南理工大学 | 2018-01-05 | — | — | CN | disclosed |
| CN-106188086-A | A kind of process preparing tetraiodofluorescein B | 北京百灵威科技有限公司 | 2016-12-07 | — | — | CN | disclosed |
| US-9182350-B2 | Naphthalene-based two-photon fluorescent probes, preparation method and use thereof | DALIAN UNIVERSITY OF TECHNOLOGY (CN) | 2015-11-10 | — | — | US | disclosed |
| EP-2778161-B1 | TWO-PHOTON FLUORESCENT PROBE USING NAPHTHALENE AS MATRIX AND PREPARATION METHOD AND USE THEREOF | UNIV DALIAN TECH (CN) | 2015-05-06 | — | — | EP | disclosed |
| US-20150079625-A1 | NAPHTHALENE-BASED TWO-PHOTON FLUORESCENT PROBES, PREPARATION METHOD AND USE THEREOF | DALIAN CHROMAS BIOSCIENCE CO., LTD (CN) | 2015-03-19 | — | — | US | disclosed |
| EP-2778161-A1 | TWO-PHOTON FLUORESCENT PROBE USING NAPHTHALENE AS MATRIX AND PREPARATION METHOD AND USE THEREOF | Dalian Chromas Bioscience Co., Ltd. (CN) | 2014-09-17 | — | — | EP | disclosed |
| CN-101605796-A | Basically pure fluorescein | ALCON MFG LTD (US) | 2009-12-16 | — | — | CN | disclosed |
| US-5976886-A | SPRAYING SURFACE WITH AQUEOUS SOLUTION OF FLUORESCIN, SODIUM HYDROXIDE, AND AN ALKALINE RESISTANT THICKENER; SPRAYING WITH HYDROGEN PEROXIDE; DETECTING FLUORESCENCE EMISSION FROM PRODUCED FLUORESCEIN; RESOLUTION, SENSITIVITY FOR FORENSICS | CHEESEMAN ROBERT (US) | 1999-11-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150079625-A1 | NAPHTHALENE-BASED TWO-PHOTON FLUORESCENT PROBES, PREPARATION METHOD AND USE THEREOF | ANXA4, ANXA3, ANTXR2 | TYMS 3195/4885ESR2 1003/4885THRB 4621/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.