Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | AOC2 | O75106 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | MMP1 | P03956 | 4/20 | 0.34 |
| ▸ | MMP2 | P08253 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MMP3 | P08254 | 2/20 | 0.34 |
| ▸ | MMP9 | P14780 | 2/20 | 0.34 |
| ▸ | MMP8 | P22894 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | MMP7 | P09237 | 1/20 | 0.34 |
| ▸ | MMP14 | P50281 | 1/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8425305 | 0.92 | MMP1 (0.37) | HSD11B1AOC2ALDH1A1MMP1MMP2 | |
| SCHEMBL8428008 | 0.83 | HSD11B1 (0.35) | HSD11B1AOC2ALDH1A1MMP1MMP2 | |
| SCHEMBL8423694 | 0.83 | PPARG (0.37) | HSD11B1AOC2ALDH1A1MMP1MMP2 | |
| SCHEMBL8426096 | 0.80 | MMP1 (0.38) | HSD11B1ALDH1A1MMP1MMP2KDM4E | |
| SCHEMBL8424027 | 0.80 | ALDH1A1 (0.36) | ALDH1A1NPC1HPGDMAPK1RAB9A | |
| SCHEMBL8425466 | 0.69 | DRD4 (0.46) | ALDH1A1MMP1MMP2MMP3MMP9 | |
| SCHEMBL8423725 | 0.69 | HSD17B10 (0.34) | HSD11B1ALDH1A1NPC1HPGDMAPK1 | |
| SCHEMBL8424173 | 0.69 | ALDH1A1 (0.36) | ALDH1A1ADAM17NPC1HPGDRAB9A | |
| SCHEMBL19110513 | 0.69 | LDHA (0.44) | ALDH1A1MAPK1RAB9ALMNAPOLB | |
| SCHEMBL8423697 | 0.67 | MMP2 (0.43) | AOC2ALDH1A1MMP1MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |