Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 known ✓ | O43570 | 1/20 | 0.33 |
| ▸ | CA1 known ✓ | P00915 | 1/20 | 0.33 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | PRKCA | P17252 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4020730 | 0.83 | RECQL (0.41) | LMNACA12CA1CA2CA9 | |
| SCHEMBL8526917 | 0.81 | RECQL (0.40) | LMNACA12CA1CA2CA9 | |
| SCHEMBL4385317 | 0.81 | CYP19A1 (0.36) | CA2MMP1MMP2MMP3MMP9 | |
| SCHEMBL5155378 | 0.79 | FAAH (0.37) | TSHR | |
| SCHEMBL354781 | 0.77 | FAAH (0.44) | LMNACA1CA2TSHR | |
| SCHEMBL11515087 | 0.76 | CA12 (0.34) | LMNACA12CA1CA2CA9 | |
| SCHEMBL1092383 | 0.75 | FAAH (0.52) | LMNACA1CA2 | |
| SCHEMBL2794860 | 0.74 | CA14 (0.35) | CA12CA1CA2CA9TSHR | |
| SCHEMBL472039 | 0.74 | RECQL (0.43) | CA2TSHRPRKCA | |
| Potassium Ion SCHEMBL7098657 | 0.73 | RECQL (0.35) | LMNAPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0635548-B1 | Thermoplastic resin composition | MITSUBISHI CHEM CORP (JP) | 1998-03-11 | — | — | EP | claimed |
| EP-0635548-A1 | Thermoplastic resin composition | MITSUBISHI CHEMICAL CORPORATION (JP) | 1995-01-25 | — | — | EP | claimed |
| EP-0635548-B1 | Thermoplastic resin composition | MITSUBISHI CHEM CORP (JP) | 1998-03-11 | — | — | EP | disclosed |
| US-5541243-A | Thermoplastic resin composition | MITSUBISHI CHEMICAL CORPORATION (JP) | 1996-07-30 | — | — | US | disclosed |
| EP-0635548-A1 | Thermoplastic resin composition | MITSUBISHI CHEMICAL CORPORATION (JP) | 1995-01-25 | — | — | EP | disclosed |